717110-61-7
Chemical Structure
VPC32183
- CAS No.: 717110-61-7
- Formula:C33H51N2O6P
- Molecular Weight:602.74
IUPAC Name: (S)-2-oleamido-3-(4-(pyridin-2-ylmethoxy)phenyl)propyl dihydrogen phosphate
InChIKey: XHZMTTZICDAOHN-KKUMVYOXSA-N
SMILES: CCCCCCCC/C=C\CCCCCCCC(N[C@H](COP(O)(O)=O)CC1=CC=C(C=C1)OCC2=CC=CC=N2)=O
Biological Activity: VPC32183 is a competitive antagonist of LPA1 and LPA3 receptors. The activity of VPC32183 can inhibit lipid phosphatase 1 (LPP1), thereby preventing the activation of ERK(1/2) by dioctanoic acid diglyceride (DGPP 8:0). By reducing the expression of LPP1, VPC32183 can further reduce DGPP 8:0-induced ERK(1/2) activation. The effects of VPC32183 suggest that it may have a positive regulatory function in cell signaling processes[1].
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VPC32183 | VPC32183 is a competitive antagonist of LPA1 and LPA3 receptors. The activity of VPC32183 can inhibit lipid phosphatase 1 (LPP1), thereby preventing the activation of ERK(1/2) by dioctanoic acid diglyceride (DGPP 8:0). By reducing the expression of LPP1, VPC32183 can further reduce DGPP 8:0-induced ERK(1/2) activation. The effects of VPC32183 suggest that it may have a positive regulatory function in cell signaling processes. | |||||||||||||||||||||
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