71865-37-7
Chemical Structure
DTME
Synonym(s): Dithio-bis-maleimidoethane
- CAS No.: 71865-37-7
- Formula:C12H12N2O4S2
- Molecular Weight:312.36
IUPAC Name: 1,1'-(disulfanediylbis(ethane-2,1-diyl))bis(1H-pyrrole-2,5-dione)
InChIKey: SGVWDRVQIYUSRA-UHFFFAOYSA-N
SMILES: O=C(C=C1)N(CCSSCCN2C(C=CC2=O)=O)C1=O
Biological Activity: DTME (Dithio-bis-maleimidoethane) is a molecular crosslinker. The molecular structure of DTME contains two maleimide groups connected by an ethane disulfide bond, and this structure enables it to react specifically with molecules containing thiol groups (such as cysteine residues) to form stable covalent bonds. DTME is commonly used to investigate and characterize protein structure (especially oligomerization) or protein interactions[1][2][3][4].
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DTME | 99.03% | DTME (Dithio-bis-maleimidoethane) is a molecular crosslinker. The molecular structure of DTME contains two maleimide groups connected by an ethane disulfide bond, and this structure enables it to react specifically with molecules containing thiol groups (such as cysteine residues) to form stable covalent bonds. DTME is commonly used to investigate and characterize protein structure (especially oligomerization) or protein interactions. | ||||||||||||||||||||
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References
- [1]. Fei Y, et al. Effect of Dioscorea tokoro Makino extract on hyperuricemia in mice. Tropical Journal of Pharmaceutical Research. 2016 Oct 5;15(9):1883-7.
- [2]. Brown JM, et al. Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing. Nucleic acid therapeutics. 2019 Oct;29(5):231-244.
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[3]. Chandra M, et al. DNA and RNA Can Be Equally Efficient Catalysts for Carbon–Carbon Bond Formation. J Am Chem Soc. 2008;130(10):2936-2937. https://doi.org/10.1021/ja7111965
[Content Brief] - [4]. Priyanka, et al. Native State Stabilization of Amyloidogenic Proteins by Kinetic Stabilizers: Inhibition of Protein Aggregation and Clinical Relevance. ChemMedChem. 2024 Oct 01;19(19):e202400244.
