71965-57-6
Chemical Structure
Globotriaosylceramide (porcine RBC)
Synonym(s): Ceramide trihexosides (porcine)
- CAS No.: 71965-57-6
- Formula:N/A
- Molecular Weight:N/A
SMILES: O[C@H]1[C@@H]([C@H](O[C@H]([C@@H]1O)OC[C@@H]([C@@H](/C=C/CCCCCCCCCCCCC)O)NC([R])=O)CO)O[C@@]2(O[C@@H]([C@@H]([C@@H]([C@H]2O)O)O[C@@]3([C@@H]([C@H]([C@H]([C@H](O3)CO)O)O)O)[H])CO)[H]
Biological Activity: Globotriaosylceramide porcine RBC (Ceramide trihexosides porcine) is a neutral glycosphingolipid belonging to the globoside series of erythrocytes, primarily isolated and extracted from porcine RBC. Globotriaosylceramide porcine RBC is a natural resistance factor against HIV-1 infection. Globotriaosylceramide porcine RBC blocks viral binding to CXCR4/CCR5 co-receptors through competitive binding to the V3 loop region of HIV-1 gp120, thereby inhibiting viral fusion and entry. Globotriaosylceramide porcine RBC is the major cell surface receptor for Shiga toxin. Globotriaosylceramide porcine RBC can be used for research on hemolytic uremic syndrome, HIV-1 infection, and Fabry disease[1][2][3][4].
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Globotriaosylceramide (porcine RBC) | Globotriaosylceramide porcine RBC (Ceramide trihexosides porcine) is a neutral glycosphingolipid belonging to the globoside series of erythrocytes, primarily isolated and extracted from porcine RBC. Globotriaosylceramide porcine RBC is a natural resistance factor against HIV-1 infection. Globotriaosylceramide porcine RBC blocks viral binding to CXCR4/CCR5 co-receptors through competitive binding to the V3 loop region of HIV-1 gp120, thereby inhibiting viral fusion and entry. Globotriaosylceramide porcine RBC is the major cell surface receptor for Shiga toxin. Globotriaosylceramide porcine RBC can be used for research on hemolytic uremic syndrome, HIV-1 infection, and Fabry disease. | |||||||||||||||||||||
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References
- [1]. Puryear WB, et al. Role of glycosphingolipids in dendritic cell-mediated HIV-1 trans-infection. In: Wu L, Schwartz O, editors. HIV interactions with dendritic cells. Advances in experimental medicine and biology. Vol. 762. New York: Springer; 2013. p. 131-53.
- [2]. Takeda Y, et al. Vero toxins (Shiga-like toxins) produced by enterohemorrhagic Escherichia coli (verocytotoxin-producing E. coli). Microbiol Immunol. 1993;37(8):591-9.
- [3]. Feldt-Rasmussen U, et al. Fabry disease: a new challenge in endocrinology and metabolism? Eur J Endocrinol. [Content Brief]
- [4]. Lingwood CA, et al. The role of glycosphingolipids in HIV/AIDS. Discovery medicine. 2011 Apr;11(59):303-13. [Content Brief]
