71997-40-5
Chemical Structure
Oxidized ATP trisodium salt
Synonym(s): oATP trisodium salt
- CAS No.: 71997-40-5
- Formula:C10H11N5Na3O13P3
- Molecular Weight:571.11
IUPAC Name: sodium (R)-2-((R)-1-(6-amino-9H-purin-9-yl)-2-oxoethoxy)-3-oxopropyl hydrogen triphosphate
InChIKey: FONDUACPXCWSBT-PXJNTPRPSA-K
SMILES: O=P(O)(O[Na])OP(OP(OC[C@H](C=O)O[C@@H](N1C2=NC=NC(N)=C2N=C1)C=O)(O[Na])=O)(O[Na])=O
Biological Activity: Oxidized ATP (oATP) trisodium salt is a broad-spectrum P2 receptor inhibitor. Oxidized ATP trisodium salt irreversibly antagonizes P2X7R activation. Oxidized ATP trisodium salt inhibits c-reactive protein (CRP)-induced NLRP3 inflammasome activation. Oxidized ATP trisodium salt can be used for research of atherosclerosis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Oxidized ATP trisodium salt | 98% | Oxidized ATP (oATP) trisodium salt is a broad-spectrum P2 receptor inhibitor. Oxidized ATP trisodium salt irreversibly antagonizes P2X7R activation. Oxidized ATP trisodium salt inhibits c-reactive protein (CRP)-induced NLRP3 inflammasome activation. Oxidized ATP trisodium salt can be used for research of atherosclerosis. | ||||||||||||||||||||
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References
- [1]. Bian F, et al. CRP-Induced NLRP3 Inflammasome Activation Increases LDL Transcytosis Across Endothelial Cells. Front Pharmacol. 2019 Jan 30;10:40. [Content Brief]
- [2]. Zhao R, et al. Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU). PLoS One. 2016 May 19;11(5):e0155953. [Content Brief]
