72029-21-1
72029-21-1
Chemical Structure
ddATP trisodium solution (100 mM)
Synonym(s): 2',3'-Dideoxyadenosine 5'-triphosphate trisodium
- CAS No.: 72029-21-1
- Formula:C10H13N5Na3O11P3
- Molecular Weight:541.13
IUPAC Name: 2-(tert-butyl) 4-methyl 2-azabicyclo[2.1.1]hexane-2,4-dicarboxylate
InChIKey: WOYWGDWPYDSCTN-PXJNTPRPSA-K
SMILES: NC1=NC=NC2=C1N=CN2[C@H]3CC[C@H](O3)COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O
Biological Activity: ddATP (2',3'-Dideoxyadenosine 5'-triphosphate) trisodium, an active metabolite of 2',3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase. ddATP trisodium can be used for Sanger method for DNA sequencing and research of virus infection[1][2][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ddATP trisodium solution (100 mM) | 98.86% | ddATP (2',3'-Dideoxyadenosine 5'-triphosphate) trisodium, an active metabolite of 2',3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase. ddATP trisodium can be used for Sanger method for DNA sequencing and research of virus infection. | ||||||||||||||||||||
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References
- [1]. van der Vliet PC, et al. Role of DNA polymerase gamma in adenovirus DNA replication. Mechanism of inhibition by 2',3'-dideoxynucleoside 5'-triphosphates. Biochemistry. 1981 Apr 28;20(9):2628-32. [Content Brief]
- [2]. Xu Lan, et al. Simultaneous determination of 2 ,3 -dideoxyinosine and the active metabolite, 2 ,3 -dideoxyadenosine-5 -triphosphate in human peripheral-blood mononuclear cell by HPLC–MS/MS and the application to cell pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:337-42. [Content Brief]
- [4]. C M Perry, et al. Didanosine. An update on its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV disease. Drugs. 1996 Dec;52(6):928-62. [Content Brief]
