727664-79-1
727664-79-1
Chemical Structure
Thr101
- CAS No.: 727664-79-1
- Formula:C14H10FNOS
- Molecular Weight:259.30
IUPAC Name: 6-fluoro-2-(o-tolyl)benzo[d]isothiazol-3(2H)-one
InChIKey: BUIZTXXZBDUOCR-UHFFFAOYSA-N
SMILES: O=C1N(SC2=CC(F)=CC=C12)C3=CC=CC=C3C
Biological Activity: Thr101 is an inhibitor (IC50=2.9 μM) of phosphomannose isomerase (PMI).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Thr101 | 99.48% | Thr101 is an inhibitor (IC50=2.9 μM) of phosphomannose isomerase (PMI).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia). | ||||||||||||||||||||
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