727972-45-4
Chemical Structure
ALT-946 free base
- CAS No.: 727972-45-4
- Formula:C5H13N5O
- Molecular Weight:159.19
InChIKey: LIXUJNFJCDOFDF-UHFFFAOYSA-N
SMILES: O=C(C)NCCNC(NN)=N
Biological Activity: ALT-946 free base is an orally active inhibitor of the advanced glycation end product (AGE) formation pathway. ALT-946 free base blocks the formation of AGE-protein cross-links, reduces the accumulation of AGE in renal tissues, alleviates increased albuminuria and elevated glomerular filtration rate, prevents glomerulosclerosis, ameliorates medullary tubulointerstitial lesions, and reduces cortical tubular degeneration. ALT-946 free base can be used in research related to diabetic nephropathy and diabetic cardiovascular diseases[1][2][3].
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ALT-946 free base | ALT-946 free base is an orally active inhibitor of the advanced glycation end product (AGE) formation pathway. ALT-946 free base blocks the formation of AGE-protein cross-links, reduces the accumulation of AGE in renal tissues, alleviates increased albuminuria and elevated glomerular filtration rate, prevents glomerulosclerosis, ameliorates medullary tubulointerstitial lesions, and reduces cortical tubular degeneration. ALT-946 free base can be used in research related to diabetic nephropathy and diabetic cardiovascular diseases. | |||||||||||||||||||||
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References
- [1]. Forbes JM, et al. Renoprotective effects of a novel inhibitor of advanced glycation. Diabetologia. 2001 Jan;44(1):108-14. [Content Brief]
- [2]. Thomas MC, et al. The role of AGEs and AGE inhibitors in diabetic cardiovascular disease. Current drug targets. 2005 Jun;6(4):453-74.
- [3]. Wilkinson-Berka JL, et al. ALT-946 and aminoguanidine, inhibitors of advanced glycation, improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat. Diabetes. 2002 Nov;51(11):3283-9.
