728912-45-6
Chemical Structure
Pentafluorobenzenesulfonyl fluorescein
- CAS No.: 728912-45-6
- Formula:C26H11F5O7S
- Molecular Weight:562.42
IUPAC Name: 3'-hydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-6'-yl 2,3,4,5,6-pentafluorobenzenesulfonate
InChIKey: UIBLLPHZQUTIBL-UHFFFAOYSA-N
SMILES: FC1=C(C(F)=C(C(F)=C1S(OC2=CC=C3C4(C5=C(OC3=C2)C=C(O)C=C5)OC(C6=CC=CC=C64)=O)(=O)=O)F)F
Biological Activity: Pentafluorobenzenesulfonyl fluorescein is a H2O2-selective sensor that can be used to detect H2O2 levels in cells. Pentafluorobenzenesulfonyl fluorescein is generally non-fluorescent, but emits fluorescence when its sulfonyl bond undergoes perhydrolysis by H2O2. Pentafluorobenzenesulfonyl fluorescein undergoes slight cleavage of its sulfonate ester bond by [Cu (phen)2]2+, and can detect hydrogen peroxide around the ablation sites of fin tissues and keratinocytes in zebrafish larvae[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pentafluorobenzenesulfonyl fluorescein | 98.30% | Pentafluorobenzenesulfonyl fluorescein is a H2O2-selective sensor that can be used to detect H2O2 levels in cells. Pentafluorobenzenesulfonyl fluorescein is generally non-fluorescent, but emits fluorescence when its sulfonyl bond undergoes perhydrolysis by H2O2. Pentafluorobenzenesulfonyl fluorescein undergoes slight cleavage of its sulfonate ester bond by [Cu (phen)2]2+, and can detect hydrogen peroxide around the ablation sites of fin tissues and keratinocytes in zebrafish larvae. | ||||||||||||||||||||
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References
- [1]. Waldron AL, et al. Oxidative stress-dependent MMP-13 activity underlies glucose neurotoxicity. J Diabetes Complications. 2018 Mar;32(3):249-257.
- [2]. Leichnitz S, et al. A fluorescence assay for the detection of hydrogen peroxide and hydroxyl radicals generated by metallonucleases. Chem Commun (Camb). 2018;54(95):13411-13414. [Content Brief]
- [3]. Rieger S, et al. Hydrogen peroxide promotes injury-induced peripheral sensory axon regeneration in the zebrafish skin. PLoS Biol. 2011;9(5):e1000621. [Content Brief]
