73547-61-2
73547-61-2
Chemical Structure
Ceftazidime sodium
Synonym(s): GR20263 sodium
- CAS No.: 73547-61-2
- Formula:C22H21N6NaO7S2
- Molecular Weight:568.56
InChIKey: JEEWDSDYUSEQML-ROMZVAKDSA-M
SMILES: [O-]C(C1=C(C[N+]2=CC=CC=C2)CS[C@@]([C@@H]3NC(/C(C4=CSC(N)=N4)=N\OC(C)(C)C(O[Na])=O)=O)([H])N1C3=O)=O
Biological Activity: Ceftazidime sodium (GR20263 sodium), an Antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime sodium is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases[1][2][3][4].
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Ceftazidime sodium | Ceftazidime sodium (GR20263 sodium), an Antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime sodium is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases. | |||||||||||||||||||||
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References
- [1]. Richards DM, et al. Ceftazidime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1985 Feb;29(2):105-61. [Content Brief]
- [2]. Esmat Kamali, et al. In vitro activities of cellulase and ceftazidime, alone and in combination against Pseudomonas aeruginosa biofilms. BMC Microbiol. 2021 Dec 16;21(1):347. [Content Brief]
- [3]. Qiuxia Lin, et al. Avibactam potentiated the activity of both ceftazidime and aztreonam against S. maltophilia clinical isolates in vitro. BMC Microbiol. 2021 Feb 22;21(1):60. [Content Brief]
- [4]. Shawn H MacVane, et al. Unexpected in vivo activity of ceftazidime alone and in combination with avibactam against New Delhi metallo-β-lactamase-producing Enterobacteriaceae in a murine thigh infection model. Antimicrob Agents Chemother. 2014 Nov;58(11):7007-9. [Content Brief]
