73572-58-4
Chemical Structure
Boc-Phe-Leu-Phe-Leu-Phe
Synonym(s): L-BOC2
- CAS No.: 73572-58-4
- Formula:C44H59N5O8
- Molecular Weight:785.97
IUPAC Name: (tert-butoxycarbonyl)-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-leucyl-L-phenylalanine
InChIKey: NGNZQSPFQJCBJQ-LTLCPEALSA-N
SMILES: CC(C)(C)OC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)CC3=CC=CC=C3)=O)=O)=O
Biological Activity: Boc-Phe-Leu-Phe-Leu-Phe (Boc-FLFLF) is a N-formyl peptide receptors (FPR) inhibitor. Boc-Phe-Leu-Phe-Leu-Phe abolishes the FMLP-induced release of peptide leukotrienes. Boc-Phe-Leu-Phe-Leu-Phe inhibits the sprouting of human umbilical vein endothelial cell (HUVEC) spheroids mediated by proliferative diabetic retinopathy (PDR) vitreous and vascular endothelial growth factor (VEGF) respectively in a three-dimensional fibrin gel. Boc-Phe-Leu-Phe-Leu-Phe inhibits the anti-inflammatory and antifibrotic effects of Ac2-26 (HY-P1098). Boc-Phe-Leu-Phe-Leu-Phe can be used for the study of immunology[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Boc-Phe-Leu-Phe-Leu-Phe | 98.10% | Boc-Phe-Leu-Phe-Leu-Phe (Boc-FLFLF) is a N-formyl peptide receptors (FPR) inhibitor. Boc-Phe-Leu-Phe-Leu-Phe abolishes the FMLP-induced release of peptide leukotrienes. Boc-Phe-Leu-Phe-Leu-Phe inhibits the sprouting of human umbilical vein endothelial cell (HUVEC) spheroids mediated by proliferative diabetic retinopathy (PDR) vitreous and vascular endothelial growth factor (VEGF) respectively in a three-dimensional fibrin gel. Boc-Phe-Leu-Phe-Leu-Phe inhibits the anti-inflammatory and antifibrotic effects of Ac2-26 (HY-P1098). Boc-Phe-Leu-Phe-Leu-Phe can be used for the study of immunology. | ||||||||||||||||||||
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References
- [1]. Rezzola S, et al. Inflammation and N-formyl peptide receptors mediate the angiogenic activity of human vitreous humour in proliferative diabetic retinopathy. Diabetologia. 2017 Apr;60(4):719-728. [Content Brief]
- [2]. Nawaz MI, et al. D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor 3. Angiogenesis. 2020 Aug;23(3):357-369. [Content Brief]
- [3]. Lefer AM, Roth DM, Kugler JL, Smith JB. Modulation of receptor mediated leukotriene release in the perfused heart. Gen Pharmacol. 1986;17(4):437-40. [Content Brief]
- [4]. Fan JH, et al. Mechanism of annexin A1/N-formylpeptide receptor regulation of macrophage function to inhibit hepatic stellate cell activation through Wnt/β-catenin pathway. World J Gastroenterol. 2023 Jun 14;29(22):3422-3439. [Content Brief]
- [5]. Liao WI, et al. Ac2-26, an Annexin A1 Peptide, Attenuates Ischemia-Reperfusion-Induced Acute Lung Injury. Int J Mol Sci. 2017 Aug 15;18(8):1771. [Content Brief]
