736144-17-5
736144-17-5
Chemical Structure
Cathepsin K-IN-11
- CAS No.: 736144-17-5
- Formula:C16H23NO3
- Molecular Weight:277.36
IUPAC Name: (S)-1-phenylpropan-2-yl ((S)-1-oxohexan-2-yl)carbamate
InChIKey: WNKGMQLRHKONID-ZFWWWQNUSA-N
SMILES: C([C@@H](OC(N[C@@H](CCCC)C=O)=O)C)C1=CC=CC=C1
Biological Activity: Cathepsin K-IN-11 is a cysteine protease inhibitor. Cathepsin K-IN-11 forms a covalent hemithioketal through its aldehyde group with the active-site cysteine, exhibiting selectivity for Cathepsin K (IC50 = 1.8 nM) over Cathepsin B (IC50 = 460 nM) and Cathepsin L (IC50 = 740 nM). Cathepsin K-IN-11 can be used for research on osteoporosis[1].
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Cathepsin K-IN-11 | Cathepsin K-IN-11 is a cysteine protease inhibitor. Cathepsin K-IN-11 forms a covalent hemithioketal through its aldehyde group with the active-site cysteine, exhibiting selectivity for Cathepsin K (IC50 = 1.8 nM) over Cathepsin B (IC50 = 460 nM) and Cathepsin L (IC50 = 740 nM). Cathepsin K-IN-11 can be used for research on osteoporosis. | |||||||||||||||||||||
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