73711-18-9
Chemical Structure
Bis-Q
- CAS No.: 73711-18-9
- Formula:C20H30I2N4
- Molecular Weight:580.29
IUPAC Name: (E)-1,1'-(diazene-1,2-diylbis(4,1-phenylene))bis(N,N,N-trimethylmethanaminium) iodide
InChIKey: MECSIHVOSZRVFP-ZPZFBZIMSA-L
SMILES: C[N+](C)(CC1=CC=C(C=C1)/N=N/C2=CC=C(C=C2)C[N+](C)(C)C)C.[I-].[I-]
Biological Activity: Bis-Q is an acetylcholine (ACh) agonist that targets voltage-clamped muscle fibers of the fish Xenomystus nigris. Bis-Q exists in two forms: cis-Bis-Q (non-agonist) and trans-Bis-Q (agonist). Photoisomerization converts cis-Bis-Q to trans-Bis-Q, which induces agonist-induced currents. Channels activated by trans-Bis-Q and ACh have similar conductances and open times. Flashes increase the ratio of trans-Bis-Q to cis-Bis-Q until light equilibrium is reached. Further flashes transiently increase agonist-induced currents, indicating binding of trans-Bis-Q to desensitized receptors. Higher concentrations of cis-Bis-Q produce larger agonist-induced currents that decay exponentially.[1].
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Bis-Q | Bis-Q is an acetylcholine (ACh) agonist that targets voltage-clamped muscle fibers of the fish Xenomystus nigris. Bis-Q exists in two forms: cis-Bis-Q (non-agonist) and trans-Bis-Q (agonist). Photoisomerization converts cis-Bis-Q to trans-Bis-Q, which induces agonist-induced currents. Channels activated by trans-Bis-Q and ACh have similar conductances and open times. Flashes increase the ratio of trans-Bis-Q to cis-Bis-Q until light equilibrium is reached. Further flashes transiently increase agonist-induced currents, indicating binding of trans-Bis-Q to desensitized receptors. Higher concentrations of cis-Bis-Q produce larger agonist-induced currents that decay exponentially.. | |||||||||||||||||||||
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