7372-30-7
7372-30-7
Chemical Structure
Ursolic acid acetate
Synonym(s): Acetylursolic acid; 3-Acetylursolic acid
- CAS No.: 7372-30-7
- Formula:C32H50O4
- Molecular Weight:498.74
IUPAC Name: (1S,2R,4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-acetoxy-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid
InChIKey: PHFUCJXOLZAQNH-OTMOLZNZSA-N
SMILES: [H][C@]12C3=CC[C@]4([C@@](CC[C@]5(C(C)([C@H](CC[C@@]54C)OC(C)=O)C)[H])([C@@]3(CC[C@]1(CC[C@H]([C@@H]2C)C)C(O)=O)C)C)[H]
Biological Activity: Ursolic acid acetate (Acetylursolic acid) is a triterpenoid compound and an inhibitor of Plasmodium falciparum heat shock protein 90 (PfHsp90) with a KD of 8.16 μM. Ursolic acid acetate is cytotoxic to KB cells, with an IC50 value of 8.4 μM. Ursolic acid acetate can be used in tumor and antimalarial research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ursolic acid acetate | 98.0% | Ursolic acid acetate (Acetylursolic acid) is a triterpenoid compound and an inhibitor of Plasmodium falciparum heat shock protein 90 (PfHsp90) with a KD of 8.16 μM. Ursolic acid acetate is cytotoxic to KB cells, with an IC50 value of 8.4 μM. Ursolic acid acetate can be used in tumor and antimalarial research. | ||||||||||||||||||||
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Ursolic acid (Standard) | 99.86% | Ursolic acid (Standard) is the analytical standard of Ursolic acid. This product is intended for research and analytical applications. Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy. | ||||||||||||||||||||
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Corosolic acid (Standard) | 99.88% | Corosolic acid (Standard) is the analytical standard of Corosolic acid. This product is intended for research and analytical applications. Corosolic acid (Colosolic acid) isolated from the fruit of Cratoegus pinnatifida var. psilosa, was reported to have anticancer activity. Corosolic acid induces cancer cell apoptosis. | ||||||||||||||||||||
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Pomolic acid 3-acetate | Pomolic acid 3-acetate is an antitubercular agent with a MIC of 32 μM against Mycobacterium tuberculosis H37Rv. | |||||||||||||||||||||
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Uvaol diacetate | Uvaol diacetate (Compound 5) is a triterpenoid derived from the leaves of Nerium oleunder L. and is an analog of Uvaol (HY-N1109). Uvaol has protective effects against DNA damage and can also induce apoptosis in cancer cells. | |||||||||||||||||||||
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3-Acetyl-11-keto-ursolic acid | 3-Acetyl-11-keto-ursolic acid (Compound 18) is a triterpenoid compound derived from Eriobotrya japonicaleaves. 3-Acetyl-11-keto-ursolic acid has 11B-hydroxysteroid dehydrogenase 1 (11b-HSD1) inhibitory activity. 3-Acetyl-11-keto-ursolic acid can be used for anti-diabetes research. | |||||||||||||||||||||
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23-Hydroxyursolic acid | 23-Hydroxyursolic acid is a triterpenoid compound that can be isolated from guava (Psidium guajava) leaves. Guava-related extracts possess antibacterial, anti-diabetic, and anti-inflammatory activities, but the specific functions of 23-Hydroxyursolic acid require targeted experimental verification. | |||||||||||||||||||||
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3-Acetyl-beta-boswellic acid (Standard) | ≥98% | 3-Acetyl-beta-boswellic acid (Standard) is the analytical standard of 3-Acetyl-beta-boswellic acid. This product is intended for research and analytical applications. 3-Acetyl-beta-boswellic acid is a boswellic acid isolated from Boswellia serrata gum resin. | ||||||||||||||||||||
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3-O-Acetyloleanolic acid | 99.84% | 3-O-Acetyloleanolic acid (3AOA), an oleanolic acid derivative isolated from the seeds of Vigna sinensis K., induces in cancer and also exhibits anti-angiogenesis activity. | ||||||||||||||||||||
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α-Amyrin acetate | 99.93% | α-Amyrin acetate is a pentacyclic triterpenoid compound with oral activity. α-Amyrin acetate can inhibit cancer cells proliferation and induce apoptosis. α-Amyrin acetate can reduce blood glucose level. α-Amyrin acetate can be used for the researches of cancer and metabolic disease, such as breast cancer and diabetes. | ||||||||||||||||||||
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3-Epiursolic Acid (Standard) | ≥98% | 3-Epiursolic Acid (Standard) is the analytical standard of 3-Epiursolic Acid (HY-N4289). This product is intended for research and analytical applications. 3-Epiursolic Acid is a natural triterpenoid and a competitive inhibitor of Cathepsin L, with an IC50 of 6.5 μM and a Ki of 19.5 μM. 3-Epiursolic Acid acts through competitive inhibition of Cathepsin L. 3-Epiursolic Acid can be used in research on Cathepsin L inhibitors and tumor-associated proteases. | ||||||||||||||||||||
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References
- [1]. Chiang YM, et al. Cytotoxic triterpenes from the aerial roots of Ficus microcarpa. Phytochemistry. 2005 Feb;66(4):495-501. [Content Brief]
- [2]. Nndwammbi AAT, et al. Ursolic acid acetate and iso-mukaadial acetate bind to Plasmodium falciparum Hsp90, abrogating its chaperone function in vitro. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jul;397(7):5179-5192. [Content Brief]
- [3]. Gnoatto S C B, et al. Pharmacomodulation on the 3-acetylursolic acid skeleton: Design, synthesis, and biological evaluation of novel N-{3-[4-(3-aminopropyl) piperazinyl] propyl}-3-O-acetylursolamide derivatives as antimalarial agents. Bioorganic & medicinal chemistry, 2008, 16(2): 771-782.
