742112-33-0
742112-33-0
Chemical Structure
OSU-03012
Synonym(s): AR-12; PDK1 inhibitor AR-12
- CAS No.: 742112-33-0
- Formula:C26H19F3N4O
- Molecular Weight:460.45
IUPAC Name: 2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide
InChIKey: YULUCECVQOCQFQ-UHFFFAOYSA-N
SMILES: O=C(CN)NC1=CC=C(C=C1)N2N=C(C=C2C3=CC=C4C5=CC=CC=C5C=CC4=C3)C(F)(F)F
Biological Activity: OSU-03012 (AR-12; PDK1 inhibitor AR-12) is a blood-brain permeable PDK-1 inhibitor with an IC50 of 5 μM[1][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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OSU-03012 | 99.80% | OSU-03012 (AR-12; PDK1 inhibitor AR-12) is a blood-brain permeable PDK-1 inhibitor with an IC50 of 5 μM. | ||||||||||||||||||||
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OSU-03012 (Standard) | ≥98% | OSU-03012 (Standard) is the analytical standard of OSU-03012 (HY-10547). This product is intended for research and analytical applications. OSU-03012 (AR-12; PDK1 inhibitor AR-12) is a blood-brain permeable PDK-1 inhibitor with an IC50 of 5 μM. | ||||||||||||||||||||
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References
- [1]. Zhu J, et al. From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Res. 2004 Jun 15;64(12):4309-18. [Content Brief]
- [3]. Tina X Lee, et al.Growth Inhibitory and Anti-Tumour Activities of OSU-03012, a Novel PDK-1 Inhibitor, on Vestibular Schwannoma and Malignant Schwannoma Cells. Eur J Cancer [Content Brief]
