7423-93-0
Chemical Structure
3-Chloro-L-tyrosine
Synonym(s): 3-Chlorotyrosine
- CAS No.: 7423-93-0
- Formula:C9H10ClNO3
- Molecular Weight:215.64
IUPAC Name: (S)-2-amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid
InChIKey: ACWBBAGYTKWBCD-ZETCQYMHSA-N
SMILES: O=C(O)[C@@H](N)CC1=CC=C(O)C(Cl)=C1
Biological Activity: 3-Chloro-L-tyrosine is a specific biomarker in myeloperoxidase-catalyzed oxidation. 3-Chloro-L-tyrosine can be used as a molecular marker for oxidative stress and inflammation to determine whether myeloperoxidase-mediated tyrosine chlorination occurs. 3-Chloro-L-tyrosine is therefore used in the diagnosis of chlorine poisoning in forensic toxicology and in the auxiliary diagnosis of inflammation such as colorectal cancer[1][2].
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3-Chloro-L-tyrosine | 98.13% | 3-Chloro-L-tyrosine is a specific biomarker in myeloperoxidase-catalyzed oxidation. 3-Chloro-L-tyrosine can be used as a molecular marker for oxidative stress and inflammation to determine whether myeloperoxidase-mediated tyrosine chlorination occurs. 3-Chloro-L-tyrosine is therefore used in the diagnosis of chlorine poisoning in forensic toxicology and in the auxiliary diagnosis of inflammation such as colorectal cancer. | ||||||||||||||||||||
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3-Chloro-L-tyrosine (Standard) | ≥98% | 3-Chloro-L-tyrosine is a specific biomarker in myeloperoxidase-catalyzed oxidation. 3-Chloro-L-tyrosine can be used as a molecular marker for oxidative stress and inflammation to determine whether myeloperoxidase-mediated tyrosine chlorination occurs. 3-Chloro-L-tyrosine is therefore used in the diagnosis of chlorine poisoning in forensic toxicology and in the auxiliary diagnosis of inflammation such as colorectal cancer. | ||||||||||||||||||||
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References
- [1]. Nishio T, et al. Determination of 3-chloro-l-tyrosine as a novel indicator of chlorine poisoning utilizing gas chromatography-mass spectrometric analysis. Leg Med (Tokyo). 2020 Nov;47:101782. [Content Brief]
- [2]. Fleszar MG, et al. Simultaneous LC-MS/MS-Based Quantification of Free 3-Nitro-l-tyrosine, 3-Chloro-l-tyrosine, and 3-Bromo-l-tyrosine in Plasma of Colorectal Cancer Patients during Early Postoperative Period. Molecules. 2020 Nov 5;25(21):5158. [Content Brief]
