74434-59-6
Chemical Structure
Sauvagine
- CAS No.: 74434-59-6
- Formula:C202H346N56O63S
- Molecular Weight:4599.31
SMILES: O=C1CC[C@H](N1)C(NCC(N2[C@H](C(N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)[C@H](CC)C)=O)[C@@H](C)O)=O)CC(O)=O)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CC(N)=O)=O)C)=O)C)=O)CCC(N)=O)=O)CCC(N)=O)=O)CCCCN)=O)CCC(O)=O)=O)CCCCN)=O)CCC(O)=O)=O)CCC(N)=O)=O)CCCCN)=O)CCC(O)=O)=O)[C@H](CC)C)=O)CCC(O)=O)=O)[C@H](CC)C)=O)CCSC)=O)CCCCN)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(C)C)=O)CCC(O)=O)=O)CC(C)C)=O)CO)=O)CC(C)C)=O)CC(O)=O)=O)[C@H](CC)C)=O)CO)=O)[C@H](CC)C)=O)CCC3)=O)CCC2)=O)=O
Biological Activity: Sauvagine is a corticotropin-releasing factor receptor (CRFR) agonist. Sauvagine activates HM-CRF receptors to stimulate intracellular cAMP accumulation, activates PC-CRF receptors to trigger associated signaling pathways, and stimulates the hypothalamic-pituitary-adrenal axis. Sauvagine can be used for research on central nervous system and blood diseases[1][2][3].
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Sauvagine | Sauvagine is a corticotropin-releasing factor receptor (CRFR) agonist. Sauvagine activates HM-CRF receptors to stimulate intracellular cAMP accumulation, activates PC-CRF receptors to trigger associated signaling pathways, and stimulates the hypothalamic-pituitary-adrenal axis. Sauvagine can be used for research on central nervous system and blood diseases. | |||||||||||||||||||||
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References
- [1]. Kishimoto T, et al. A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle. Proc Natl Acad Sci U S A. 1995;92(4):1108-1112. [Content Brief]
- [2]. Brown MR, et al. Comparison of the biologic actions of corticotropin-releasing factor and sauvagine. Regul Pept. 1982;4(2):107-114. [Content Brief]
- [3]. Montecucchi PC, et al. Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of Phyllomedusa sauvagei. Int J Pept Protein Res. 1981;18(2):113-120. [Content Brief]
