7444-29-3
7444-29-3
Chemical Structure
Anhydroleucovorin
- CAS No.: 7444-29-3
- Formula:C20H21N7O6
- Molecular Weight:455.42
IUPAC Name: (S)-2-(4-((R)-3-amino-1-oxo-1,4,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8-ium-8-yl)benzamido)-4-carboxybutanoate
InChIKey: MEANFMOQMXYMCT-OLZOCXBDSA-N
SMILES: O=C1C2=C(NC(N)=N1)NC[C@@]3([H])N2C=[N+](C4=CC=C(C=C4)C(N[C@H](C([O-])=O)CCC(O)=O)=O)C3
Biological Activity: Anhydroleucovorin is a form of tetrahydrofolate and serves as a substrate for cyclohydrolase, which converts it to 10-formyltetrahydrofolate. Anhydroleucovorin can be used in oncology research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Anhydroleucovorin | 96.6% | Anhydroleucovorin is a form of tetrahydrofolate and serves as a substrate for cyclohydrolase, which converts it to 10-formyltetrahydrofolate. Anhydroleucovorin can be used in oncology research. | ||||||||||||||||||||
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Anhydroleucovorin (Standard) | ≥98% | Anhydroleucovorin (Standard) is the analytical standard of Anhydroleucovorin (HY-153039). This product is intended for research and analytical applications. Anhydroleucovorin is a form of tetrahydrofolate and serves as a substrate for cyclohydrolase, which converts it to 10-formyltetrahydrofolate. Anhydroleucovorin can be used in oncology research. | ||||||||||||||||||||
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LY 345899 (Standard) | ≥98% | LY 345899 (Standard) is the analytical standard of LY 345899 (HY-101943). This product is intended for research and analytical applications. LY 345899 is a Folate analog and is a methylene tetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inbhibitor with IC50 values of 96 nM and 663 nM, respectively and a Ki of 18 nM for MTHFD1. | ||||||||||||||||||||
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Arfolitixorin calcium | 95.94% | Arfolitixorin calcium is a bioactive compound that acts as an enzyme substrate. Arfolitixorin calcium is used as a substrate for methylenetetrahydrofolate reductase to generate 5-methyltetrahydrofolate. Arfolitixorin calcium may have potential applications in neurobiological research, particularly in studies related to gene expression and metabolism. Research on arfolitixorin calcium helps reveal the functional genetics of bird genes. | ||||||||||||||||||||
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5-Methyltetrahydrofolic acid (Standard) | 98.58% | 5-Methyltetrahydrofolic acid (Standard) (5-Methyl THF (Standard)) is the analytical standard of 5-Methyltetrahydrofolic acid (HY-113046). This product is intended for research and analytical applications. 5-Methyltetrahydrofolic acid (5-Methyl THF) is the main circulating form of folic acid in the body and is involved in a variety of biochemical reactions. 5-Methyltetrahydrofolic acid regulates cardiovascular function by increasing the production of endothelin-1 (ET-1) in low-density lipoprotein-treated endothelial cells and can be used in the study of cardiovascular diseases. | ||||||||||||||||||||
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5-Methyltetrahydrofolic acid-13C6 | 5-Methyltetrahydrofolic acid-13C6 (5-Methyl THF-13C6) is 13C labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is the main circulating form of folic acid in the body and is involved in a variety of biochemical reactions. 5-Methyltetrahydrofolic acid regulates cardiovascular function by increasing the production of endothelin-1 (ET-1) in low-density lipoprotein-treated endothelial cells and can be used in the study of cardiovascular diseases. | |||||||||||||||||||||
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Levoleucovorin | 98.53% | Levoleucovorin (Levofolinic acid; Levofolene) is the pharmacologically and orally active levoisomer of Folinic acid (HY-17556), a synthetic folate analogue. Levoleucovorin can inhibit LOXL2 with an IC50 of 68.81 μM. Levoleucovorin can inhibit cancer cells proliferation, migration and induce apoptosis. Levoleucovorin can be used as a rescue agent for high-dose Methotrexate (HY-14519). Levoleucovorin can reduce the frequency of embryonic malformations. Levoleucovorin can be used for the research of can and endocrinology, such as breast cancer and osteosarcoma. | ||||||||||||||||||||
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Folitixorin | 83.37% | Folitixorin (5,10-Methylenetetrafolate; ANX-510 free acid) is a reduced form of Folic acid (HY-16637) and a cofactor of thymidylate synthase. Folitixorin acts as an essential cofactor to promote the formation of a tight ternary complex between thymidylate synthase and FdUMP, thereby enhancing the inhibitory effect of FdUMP on thymidylate synthase. Folitixorin in combination with 5-fluorouracil and αVEGF reduces tumor volume in colorectal tumor models of nude mice. Folitixorin is used in related research on Yoshida sarcoma, P-388 leukemia, and colorectal cancer. | ||||||||||||||||||||
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Folitixorin calcium | Folitixorin calcium (5,10-Methylenetetrafolate calcium; ANX-510) is a reduced form of Folic acid (HY-16637) and a cofactor of thymidylate synthase. Folitixorin calcium acts as an essential cofactor to promote the formation of a tight ternary complex between thymidylate synthase and FdUMP, thereby enhancing the inhibitory effect of FdUMP on thymidylate synthase. Folitixorin calcium in combination with 5-fluorouracil and αVEGF reduces tumor volume in colorectal tumor models of nude mice. Folitixorin calcium is used in related research on Yoshida sarcoma, P-388 leukemia, and colorectal cancer. | |||||||||||||||||||||
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Levomefolic acid | 99.59% | Levomefolic acid (L-5-MTHF) is an orally active, brain-penetrant natural active form of folic acid and is one of the most widely used folic acid food supplements. | ||||||||||||||||||||
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Levomefolic acid magnesium | Levomefolic acid magnesium is an orally active, brain-penetrant natural active form of folic acid and is one of the most widely used folic acid food supplements. | |||||||||||||||||||||
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Levomefolic acid-13C5 | Levomefolic acid-13C5 is the 13C labeled Levomefolic acid. Levomefolic acid (L-5-MTHF) is an orally active, brain-penetrant natural active form of folic acid and is one of the most widely used folic acid food supplements. | |||||||||||||||||||||
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