74513-77-2
74513-77-2
Chemical Structure
Ro 363
- CAS No.: 74513-77-2
- Formula:C19H25NO6
- Molecular Weight:363.40
IUPAC Name: 4-(3-((3,4-dimethoxyphenethyl)amino)-2-hydroxypropoxy)benzene-1,2-diol
InChIKey: RFNBEBPVKCJZPV-UHFFFAOYSA-N
SMILES: OC1=CC=C(C=C1O)OCC(CNCCC2=CC=C(C(OC)=C2)OC)O
Biological Activity: Ro 363, an effective inotropic stimulant, is a potent and highly selective β1-adrenoceptor agonist. RO 363 is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility[1][2][3].
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Ro 363 | Ro 363, an effective inotropic stimulant, is a potent and highly selective β1-adrenoceptor agonist. RO 363 is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility. | |||||||||||||||||||||
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References
- [1]. Maccarrone C, et al. Comparison of the Arrhythmogenic Actions of (-)-Isoprenaline, Dobutamine and the selective beta 1-adrenoceptor agonist, (+/-)-(1-[3',4'-dihydroxyphenoxy] -2-hydroxy-[3",4"-dimethoxy phenethylamino]-propane)-oxalate (Ro 363). Arzneimit [Content Brief]
- [2]. Iakovidis D, et al. In vitro activity of RO363, a beta1-adrenoceptor selective agonist. Br J Pharmacol. 1980 Apr;68(4):677-85. [Content Brief]
- [3]. Einstein R, et al. Comparison of the cardiac effects of beta-adrenoreceptor agonists in anaesthetised and conscious dogs. J Auton Pharmacol. 1986 Mar;6(1):9-14. [Content Brief]
