74517-42-3
Chemical Structure
Ditercalinium chloride
Synonym(s): NSC335153
- CAS No.: 74517-42-3
- Formula:C46H50Cl2N6O2
- Molecular Weight:789.83
IUPAC Name: 2,2'-([4,4'-bipiperidine]-1,1'-diylbis(ethane-2,1-diyl))bis(10-methoxy-7H-pyrido[4,3-c]carbazol-2-ium) chloride
InChIKey: FWBSWSRNGHRDFZ-UHFFFAOYSA-N
SMILES: COC1=CC2=C(NC3=C2C4=C[N+](CCN5CCC(C6CCN(CC[N+]7=CC=C8C=CC(NC9=C%10C=C(OC)C=C9)=C%10C8=C7)CC6)CC5)=CC=C4C=C3)C=C1.[Cl-].[Cl-]
Biological Activity: Ditercalinium chloride is an anticancer agent. Ditercalinium chloride inhibits human DNA polymerase gamma activity. Ditercalinium chloride can deplete mitochondrial DNA in both mouse and human cells. Ditercalinium chloride is a potential ligand against the COMMD10-AP3S1 fusion protein[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ditercalinium chloride | 96.0% | Ditercalinium chloride is an anticancer agent. Ditercalinium chloride inhibits human DNA polymerase gamma activity. Ditercalinium chloride can deplete mitochondrial DNA in both mouse and human cells. Ditercalinium chloride is a potential ligand against the COMMD10-AP3S1 fusion protein. | ||||||||||||||||||||
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References
- [1]. Okamaoto M, et al. Ditercalinium chloride, a pro-anticancer drug, intimately associates with mammalian mitochondrial DNA and inhibits its replication. Curr Genet. 2003 Aug;43(5):364-70. [Content Brief]
- [2]. Sandhya Rai, et al. Ditercalinium chloride: A potential inhibitor targeting recurrent in frame COMMD10-AP3S1 fusions in CRCs. Gene Reports. 2023, 30:101739.
