7461-50-9
7461-50-9
Chemical Structure
4-Amino-2-chloropyrimidine
- CAS No.: 7461-50-9
- Formula:C4H4ClN3
- Molecular Weight:129.55
IUPAC Name: 2-chloropyrimidin-4-amine
InChIKey: LPBDZVNGCNTELM-UHFFFAOYSA-N
SMILES: ClC1=NC=CC(N)=N1
Biological Activity: 4-Amino-2-chloropyrimidine is a pyrimidine derivative. 4-Amino-2-chloropyrimidine is a competitive inhibitor for AChE (Ki = 0.18 μM) and BChE (Ki = 1.324 μM). 4-Amino-2-chloropyrimidine fits in the binding pocket of 4BDS. 4-Amino-2-chloropyrimidine has high inhibitory activity on GST enzyme activity (IC50 = 0.037 μM, Ki = 0.047 μM) in vitro[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4-Amino-2-chloropyrimidine | 99.77% | 4-Amino-2-chloropyrimidine is a pyrimidine derivative. 4-Amino-2-chloropyrimidine is a competitive inhibitor for AChE (Ki = 0.18 μM) and BChE (Ki = 1.324 μM). 4-Amino-2-chloropyrimidine fits in the binding pocket of 4BDS. 4-Amino-2-chloropyrimidine has high inhibitory activity on GST enzyme activity (IC50 = 0.037 μM, Ki = 0.047 μM) in vitro. | ||||||||||||||||||||
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2-Amino-4-chloropyrimidine | 2-Amino-4-chloropyrimidine is an aminopyrimidine derivative. | |||||||||||||||||||||
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2-Amino-6-chloropyrazine | 99.87% | 2-Amino-6-chloropyrazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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2-Amino-4-chloropyridine | 98.90% | 2-Amino-4-chloropyridine is a key intermediate. 2-Amino-4-chloropyridine derivatives exhibit antibacterial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. | ||||||||||||||||||||
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2-O-Methylcytosine (Standard) | ≥98% | 2-O-Methylcytosine (Standard) is the analytical standard of 2-O-Methylcytosine. This product is intended for research and analytical applications. 2-O-Methylcytosine, an O-alkylated analogue a DNA adduct, is the damaged nucleobase. | ||||||||||||||||||||
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3-Chloro-2-pyrazinamine | 3-Chloro-2-pyrazinamine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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4-Amino-2,6-dichloropyrimidine | 99.03% | 2,6-Dichloro pyrimidine -4-amine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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2-Chloro-5-methylpyrimidin-4-amine-15N2,13C | 2-Chloro-5-methylpyrimidin-4-amine-15N2,13C (4-Amino-2-chloro-5-methylpyrimidine-15N2,13C) is the 13C- and 15N-labeled 2-Chloro-5-methylpyrimidin-4-amine (HY-W002966). | |||||||||||||||||||||
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3-Amino-6-chloropyridazine | 98.0% | 3-Amino-6-chloropyridazine is a nitrogen-containing heterocyclic organic compound belonging to the pyridazine derivatives. 3-Amino-6-chloropyridazine has the basicity of amino groups and the nucleophilic substitution activity of chlorine atoms. 3-Amino-6-chloropyridazine can serve as an important intermediate for synthesizing some active compounds. | ||||||||||||||||||||
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2-Chloropyridin-3-amine | 99.95% | 2-Chloropyridin-3-amine is a heterocyclic amine that serves as a pharmaceutical intermediate for the synthesis of dihydroorotate dehydrogenase (DHODH) inhibitors. | ||||||||||||||||||||
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2-Amino-5-chloropyridine (Standard) | ≥98% | 2-Amino-5-chloropyridine (Standard) is the analytical standard of 2-Amino-5-chloropyridine. This product is intended for research and analytical applications. | ||||||||||||||||||||
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References
- [1]. Duran H. E. (2023). Pyrimidines: Molecular docking and inhibition studies on carbonic anhydrase and cholinesterases. Biotechnology and applied biochemistry, 70(1), 68–82. [Content Brief]
- [2]. O'Hare, T., et al., (2004). Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML. Blood, 104(8), 2532–2539. [Content Brief]
