746661-90-5
746661-90-5
Chemical Structure
MC4R antagonist-3 hydrochloride
- CAS No.: 746661-90-5
- Formula:C34H51Cl2N5O2
- Molecular Weight:632.71
InChIKey: RYKMQAYZCJQJKH-UHFFFAOYSA-N
SMILES: O=C(N(CCC(C)C)CCC(C)C)C1=CC2=C(N=C(N2CCCN3CCCCC3)NC4=CC=C(C(C)=O)C=C4)C=C1.Cl.Cl
Biological Activity: MC4R antagonist-3 hydrochloride is a selective melanocortin-4 receptor (MC4R) antagonist with a Kd value of 2 nM. MC4R antagonist-3 hydrochloride binds to MC4R and alters its conformation, specifically promoting ERK1/2 phosphorylation in constitutively active mutants while inhibiting basal cAMP production. MC4R antagonist-3 hydrochloride can be used for research on obesity[1].
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MC4R antagonist-3 hydrochloride | MC4R antagonist-3 hydrochloride is a selective melanocortin-4 receptor (MC4R) antagonist with a Kd value of 2 nM. MC4R antagonist-3 hydrochloride binds to MC4R and alters its conformation, specifically promoting ERK1/2 phosphorylation in constitutively active mutants while inhibiting basal cAMP production. MC4R antagonist-3 hydrochloride can be used for research on obesity. | |||||||||||||||||||||
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