74685-16-8
Chemical Structure
Picenadol hydrochloride
Synonym(s): LY-150720 hydrochloride
- CAS No.: 74685-16-8
- Formula:C16H26ClNO
- Molecular Weight:283.84
IUPAC Name: 3-((3R,4S)-1,3-dimethyl-4-propylpiperidin-4-yl)phenol hydrochloride
InChIKey: GUSQVRBQQVKTMO-LINSIKMZSA-N
SMILES: CCC[C@@]1(C2=CC(O)=CC=C2)[C@H](CN(C)CC1)C.Cl
Biological Activity: Picenadol (LY-150720) hydrochloride is an opioid mixed agonist-antagonist analgesic. Picenadol hydrochloride is an external racemic mixture, where its d-isomer (LY136596) is a potent μ-opioid receptor agonist, and the l-isomer (LY136595) is a weak μ-receptor competitive antagonist, which can inhibit the agonist effect and reduce the risk of dependence. Picenadol hydrochloride has anticholinergic activity[1][2].
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Picenadol hydrochloride | Picenadol (LY-150720) hydrochloride is an opioid mixed agonist-antagonist analgesic. Picenadol hydrochloride is an external racemic mixture, where its d-isomer (LY136596) is a potent μ-opioid receptor agonist, and the l-isomer (LY136595) is a weak μ-receptor competitive antagonist, which can inhibit the agonist effect and reduce the risk of dependence. Picenadol hydrochloride has anticholinergic activity. | |||||||||||||||||||||
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References
- [1]. Carter RB, et al. Effects of LY150720 (picenadol), a novel mixed-action opioid, on schedule-controlled responding in the squirrel monkey. Pharmacol Biochem Behav. 1984 Nov;21(5):779-86. [Content Brief]
- [2]. Zimmerman DM, et al. Picenadol. Drug Alcohol Depend. 1985 Feb;14(3-4):381-401. [Content Brief]
