748810-28-8
Chemical Structure
Vernakalant Hydrochloride
Synonym(s): RSD1235 hydrochloride
- CAS No.: 748810-28-8
- Formula:C20H32ClNO4
- Molecular Weight:385.93
IUPAC Name: (R)-1-((1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexyl)pyrrolidin-3-ol hydrochloride
InChIKey: JMHYCBFEEFHTMK-IIUXMCBISA-N
SMILES: COC1=C(OC)C=C(CCO[C@H]2[C@H](N3CC[C@@H](O)C3)CCCC2)C=C1.Cl
Biological Activity: Vernakalant hydrochloride is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker. IC50 for block by Vernakalant of wild-type and mutant Kv1.5 channels Fractional block is 13.35±0.93 μM, 0.61±0.03 μM, and 1.63±0.09 μM for Kv1.5 channelwt, Kv1.5 channelI508F, Kv1.5 channelT479A, respectively.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Vernakalant Hydrochloride | 99.33% | Vernakalant hydrochloride is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker. IC50 for block by Vernakalant of wild-type and mutant Kv1.5 channels Fractional block is 13.35±0.93 μM, 0.61±0.03 μM, and 1.63±0.09 μM for Kv1.5 channelwt, Kv1.5 channelI508F, Kv1.5 channelT479A, respectively. | ||||||||||||||||||||
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Vernakalant-d6 hydrochloride | 98.95% | Vernakalant-d6 (hydrochloride) is deuterium labeled Vernakalant. | ||||||||||||||||||||
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