74938-88-8
Chemical Structure
p-APMSF hydrochloride
Synonym(s): p-Amidinophenylmethylsulfonylfluoride hydrochloride
- CAS No.: 74938-88-8
- Formula:C8H10ClFN2O2S
- Molecular Weight:252.69
IUPAC Name: (4-carbamimidoylphenyl)methanesulfonyl fluoride hydrochloride
InChIKey: KHLLRHIUKOJXLL-UHFFFAOYSA-N
SMILES: O=S(CC1=CC=C(C(N)=N)C=C1)(F)=O.[H]Cl
Biological Activity: p-APMSF (p-Amidinophenylmethylsulfonylfluoride) hydrochloride is a serine protease and trypsin inhibitor with the characteristic of rapid onset of action. p-APMSF hydrochloride reduces the enzymatic hydrolysis of recombinant human G-CSF in rat pulmonary mucosa. Combined intratracheal treatment with p-APMSF hydrochloride and Laureth-9 significantly enhances its absorption efficiency in rat lungs. Following intranasal administration, p-APMSF hydrochloride does not increase the concentration of recombinant human G-CSF in rat plasma, nor does it alter the effect of G-CSF on inducing an increase in total white blood cell count[1][2][3].
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p-APMSF hydrochloride | 95.0% | p-APMSF (p-Amidinophenylmethylsulfonylfluoride) hydrochloride is a serine protease and trypsin inhibitor with the characteristic of rapid onset of action. p-APMSF hydrochloride reduces the enzymatic hydrolysis of recombinant human G-CSF in rat pulmonary mucosa. Combined intratracheal treatment with p-APMSF hydrochloride and Laureth-9 significantly enhances its absorption efficiency in rat lungs. Following intranasal administration, p-APMSF hydrochloride does not increase the concentration of recombinant human G-CSF in rat plasma, nor does it alter the effect of G-CSF on inducing an increase in total white blood cell count. | ||||||||||||||||||||
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References
- [1]. Mitsuda S, et al. A receptor-mediated antigen delivery and incorporation system: administration of α2-macroglobulin-cytochrome c conjugate induced high concentrations of antibodies against cytochrome c in mice[J]. Biochemical and biophysical research communications, 1993, 191(3): 1326-1331.
- [2]. Machida M, et al. The effects of absorption enhancers on the pulmonary absorption of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in rats. Biol Pharm Bull. 2000;23(1):84-86. [Content Brief]
- [3]. Machida M, et al. Effects of surfactants and protease inhibitors on nasal absorption of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in rats. Biol Pharm Bull. 1994;17(10):1375-1378. [Content Brief]
