75041-32-6
Chemical Structure
NSC-134754
Synonym(s): NZ-28
- CAS No.: 75041-32-6
- Formula:C27H34N2O2
- Molecular Weight:418.57
IUPAC Name: (S)-3-ethyl-9,10-dimethoxy-2-(((R)-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-1,6,7,11b-tetrahydro-4H-pyrido[2,1-a]isoquinoline
InChIKey: HDIJLRXRAJUXQB-RPBOFIJWSA-N
SMILES: COC1=C(C=C(C2=C1)CCN3CC(CC)=C(C[C@]32[H])C[C@H]4NCCC5=C4C=CC=C5)OC
Biological Activity: NSC-134754 (NZ-28) is a dehydroemetine derivative and heat shock protein (HSP) induction inhibitor. NSC-134754 acts at the post-transcriptional level, targets Hsp72 and Hsp27, and does not alter general protein synthesis, HSF-1 transcriptional activity, or Hsp mRNA levels. NSC-134754 can be used for the research of multiple myeloma, prostate carcinoma, colon carcinoma[1].
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NSC-134754 | NSC-134754 (NZ-28) is a dehydroemetine derivative and heat shock protein (HSP) induction inhibitor. NSC-134754 acts at the post-transcriptional level, targets Hsp72 and Hsp27, and does not alter general protein synthesis, HSF-1 transcriptional activity, or Hsp mRNA levels. NSC-134754 can be used for the research of multiple myeloma, prostate carcinoma, colon carcinoma. | |||||||||||||||||||||
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