750531-54-5
750531-54-5
Chemical Structure
A-61603 (free base）
- CAS No.: 750531-54-5
- Formula:C14H19N3O3S
- Molecular Weight:309.38
IUPAC Name: N-(5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)methanesulfonamide
InChIKey: OQFCXJDXHCDLHX-UHFFFAOYSA-N
SMILES: CS(=O)(NC1=C2CCCC(C2=CC=C1O)C3=NCCN3)=O
Biological Activity: A-61603 free base is a potent adrenergic receptor agonist. A-61603 free base reduces carotid artery conductance in anesthetized pigs mediated by α1 and α2 adrenergic receptors (pEC50=7.25). A-61603 free base can be used as a probe to study adrenergic function[1][2].
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A-61603 (free base） | A-61603 free base is a potent adrenergic receptor agonist. A-61603 free base reduces carotid artery conductance in anesthetized pigs mediated by α1 and α2 adrenergic receptors (pEC50=7.25). A-61603 free base can be used as a probe to study adrenergic function. | |||||||||||||||||||||
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References
- [1]. Knepper S M, et al. A-61603, a potent alpha 1-adrenergic receptor agonist, selective for the alpha 1A receptor subtype[J]. Journal of Pharmacology and Experimental Therapeutics, 1995, 274(1): 97-103. [Content Brief]
- [2]. Mehrotra S, et al. A61603‐Induced Contractions of the Porcine Meningeal Artery Are Mediated by α1‐and α2‐Adrenoceptors[J]. Basic & clinical pharmacology & toxicology, 2007, 100(4): 279-285. [Content Brief]
