750575-23-6
Chemical Structure
AG-024104
- CAS No.: 750575-23-6
- Formula:C24H28F2N6O4S2
- Molecular Weight:566.64
IUPAC Name: (4-amino-2-((1-((6-(2-(dimethylamino)ethoxy)pyridin-3-yl)sulfonyl)piperidin-4-yl)amino)thiazol-5-yl)(2,6-difluorophenyl)methanone
InChIKey: OBHOHFUFLKWHSB-UHFFFAOYSA-N
SMILES: O=C(C=1SC(=NC1N)NC2CCN(CC2)S(=O)(=O)C3=CN=C(OCCN(C)C)C=C3)C=4C(F)=CC=CC4F
Biological Activity: AG-024104 is a CDK inhibitor with Ki values of 2.3 nM (CDK1/cyclinB), 1.8 nM (CDK2/cyclinA), and 0.67 nM (CDK4/cyclinD). AG-024104 functionally inhibits kinase activity of CDK1/cyclinB, CDK2/cyclinA, and CDK4/cyclinD. AG-024104 serves as a negative control for peripheral leukocyte toxicity studies in preclinical development[1].
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AG-024104 | AG-024104 is a CDK inhibitor with Ki values of 2.3 nM (CDK1/cyclinB), 1.8 nM (CDK2/cyclinA), and 0.67 nM (CDK4/cyclinD). AG-024104 functionally inhibits kinase activity of CDK1/cyclinB, CDK2/cyclinA, and CDK4/cyclinD. AG-024104 serves as a negative control for peripheral leukocyte toxicity studies in preclinical development. | |||||||||||||||||||||
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