75252-12-9
Chemical Structure
7-Methyl-diguanosine triphosphate ammonium solution (100 mM)
Synonym(s): m7Gp3G ammonium
- CAS No.: 75252-12-9
- Formula:C21H35N12O18P3
- Molecular Weight:836.49
InChIKey: RMORGOQTGFXHBX-DQNSRKNCSA-N
SMILES: O=P(O)(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2NC(N)=NC3=O)O1)OP(OP(OC[C@H]4O[C@@H](N5C(NC(N)=N6)=C([N+](C)=C5)C6=O)[C@H](O)[C@@H]4O)([O-])=O)(O)=O.N.N
Biological Activity: 7-Methyl-diguanosine triphosphate (m7Gp3G) ammonium is an mRNA cap structure analog that inhibits in vitro protein synthesis by binding to the translation initiation complex. 7-Methyl-diguanosine triphosphate ammonium binds to eIF4E, promotes cap-dependent translation initiation, stabilizes mRNA, and acts as a translation enhancer. 7-Methyl-diguanosine triphosphate ammonium can be used to prepare synthetic capped RNA transcripts for studies related to mRNA translation, splicing, turnover, and intracellular transport[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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7-Methyl-diguanosine triphosphate ammonium solution (100 mM) | 98.83% | 7-Methyl-diguanosine triphosphate (m7Gp3G) ammonium is an mRNA cap structure analog that inhibits in vitro protein synthesis by binding to the translation initiation complex. 7-Methyl-diguanosine triphosphate ammonium binds to eIF4E, promotes cap-dependent translation initiation, stabilizes mRNA, and acts as a translation enhancer. 7-Methyl-diguanosine triphosphate ammonium can be used to prepare synthetic capped RNA transcripts for studies related to mRNA translation, splicing, turnover, and intracellular transport. | ||||||||||||||||||||
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References
- [1]. Grudzien E, et al. Differential inhibition of mRNA degradation pathways by novel cap analogs. J Biol Chem. 2006;281(4):1857-1867. [Content Brief]
- [2]. Grudzien-Nogalska E, et al. Synthesis of anti-reverse cap analogs (ARCAs) and their applications in mRNA translation and stability. Methods Enzymol. 2007;431:203-227. [Content Brief]
