75483-04-4
75483-04-4
Chemical Structure
Nrf2 activator-10
- CAS No.: 75483-04-4
- Formula:C13H12ClNO3
- Molecular Weight:265.69
IUPAC Name: ethyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate
InChIKey: XUJQDJGGHFNYDY-UHFFFAOYSA-N
SMILES: O=C(C1=C(Cl)C2=C(C=CC=C2)N(C)C1=O)OCC
Biological Activity: Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent inducer for antioxidant response element (ARE) (EC50 is 2.7 μM) and an activator for Nrf2. Nrf2 activator-10 modifies Keap1, blocks Cul3-Keap1 ubiquitin ligase complex, activates the transcription of Nrf2. Nrf2 activator-10 protects cells from H2O2-induced apoptosis.
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Nrf2 activator-10 | 98.65% | Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent inducer for antioxidant response element (ARE) (EC50 is 2.7 μM) and an activator for Nrf2. Nrf2 activator-10 modifies Keap1, blocks Cul3-Keap1 ubiquitin ligase complex, activates the transcription of Nrf2. Nrf2 activator-10 protects cells from H2O2-induced apoptosis. | ||||||||||||||||||||
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