76-38-0
Chemical Structure
Methoxyflurane
Synonym(s): DA-759
- CAS No.: 76-38-0
- Formula:C3H4Cl2F2O
- Molecular Weight:164.97
IUPAC Name: 2,2-dichloro-1,1-difluoro-1-methoxyethane
InChIKey: RFKMCNOHBTXSMU-UHFFFAOYSA-N
SMILES: COC(F)(F)C(Cl)Cl
Biological Activity: Methoxyflurane (DA-759) is a volatile anesthetic and nephrotoxic agent. Methoxyflurane undergoes defluorination to generate inorganic fluoride and oxalic acid, leading to polyuric renal insufficiency, proximal tubular necrosis, mitochondrial swelling, and ADH-resistant polyuria. Methoxyflurane inhibits Na+/K+ ATPase sodium transport. Methoxyflurane is used in research on neurological diseases and kidney diseases[1][2][3][4][5][6].
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Methoxyflurane | 98.0% | Methoxyflurane (DA-759) is a volatile anesthetic and nephrotoxic agent. Methoxyflurane undergoes defluorination to generate inorganic fluoride and oxalic acid, leading to polyuric renal insufficiency, proximal tubular necrosis, mitochondrial swelling, and ADH-resistant polyuria. Methoxyflurane inhibits Na+/K+ ATPase sodium transport. Methoxyflurane is used in research on neurological diseases and kidney diseases. | ||||||||||||||||||||
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References
- [1]. Mazze RI. Methoxyflurane nephropathy. Environmental Health Perspectives. 1976 Jun;15:111.
- [2]. Kharasch ED, et al. Human kidney methoxyflurane and sevoflurane metabolism: intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity. Anesthesiology. 1995 Mar 1;82(3):689-99.
- [3]. Berman ML, et al. Nonspecific stimulation of drug metabolism in rats by methoxyflurane. Anesthesiology. 1970 Jun 1;32(6):500-6.
- [4]. Kharasch ED, et al. New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites. Anesthesiology. 2006 Oct 1;105(4):737-45.
- [5]. Jenkins A, et al. Actions of general anaesthetics on 5-HT3 receptors in N1E-115 neuroblastoma cells. British journal of pharmacology. 1996 Apr;117(7):1507-15.
- [6]. Pocock G, et al. The action of volatile anaesthetics on stimulus-secretion coupling in bovine adrenal chromaffin cells. British journal of pharmacology. 1988 Sep;95(1):209-17.
