7608-44-8
Chemical Structure
Artocarpin
- CAS No.: 7608-44-8
- Formula:C26H28O6
- Molecular Weight:436.50
IUPAC Name: (E)-2-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-1-en-1-yl)-3-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
InChIKey: KRGDFVQWQJIMEK-RMKNXTFCSA-N
SMILES: C/C(C)=C\CC1=C(C2=C(C=C(O)C=C2)O)OC3=CC(OC)=C(/C=C/C(C)C)C(O)=C3C1=O
Biological Activity: Artocarpin is an orally active apoptosis inducer. Artocarpin targets NF-κB, Erk1/2, p38 MAPK, AktS473, p53, Akt 1 kinase and Akt 2 kinase. Artocarpin induces reactive oxygen species (ROS) production, mediates p53-dependent and p53-independent apoptotic signaling pathways, induces G1-phase cell cycle arrest, and triggers autophagic cell death. Artocarpin exerts cytotoxic and bactericidal effects on cancer cells, reduces bacterial load, and exhibits anti-inflammatory, analgesic and anti-angiogenic activities[1][2][3][4][5][6][7].
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Artocarpin | Artocarpin is an orally active apoptosis inducer. Artocarpin targets NF-κB, Erk1/2, p38 MAPK, AktS473, p53, Akt 1 kinase and Akt 2 kinase. Artocarpin induces reactive oxygen species (ROS) production, mediates p53-dependent and p53-independent apoptotic signaling pathways, induces G1-phase cell cycle arrest, and triggers autophagic cell death. Artocarpin exerts cytotoxic and bactericidal effects on cancer cells, reduces bacterial load, and exhibits anti-inflammatory, analgesic and anti-angiogenic activities. | |||||||||||||||||||||
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References
- [1]. Tsai MH, et al. Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and Akt activation in non-small cell lung cancer cells. Oncotarget. 2017;8(17):28342-28358. [Content Brief]
- [2]. Sun G, et al. Chemoprevention of Colorectal Cancer by Artocarpin, a Dietary Phytochemical from Artocarpus heterophyllus. J Agric Food Chem. 2017;65(17):3474-3480. [Content Brief]
- [3]. Arung ET, et al. Inhibitory effect of isoprenoid-substituted flavonoids isolated from Artocarpus heterophyllus on melanin biosynthesis. Planta Med. 2006;72(9):847-850. [Content Brief]
- [4]. Wang YH, et al. New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama. J Nat Prod. 2004;67(5):757-761. [Content Brief]
- [5]. Han AR, et al. Prenylated flavonoids from the heartwood of Artocarpus communis with inhibitory activity on lipopolysaccharide-induced nitric oxide production. J Nat Prod. 2006;69(4):719-721. [Content Brief]
- [6]. Meenu MT, et al. Developing the Natural Prenylflavone Artocarpin from Artocarpus hirsutus as a Potential Lead Targeting Pathogenic, Multidrug-Resistant Staphylococcus aureus, Persisters and Biofilms with No Detectable Resistance. J Nat Prod. 2022 Oct 28;85(10):2413-2423. [Content Brief]
- [7]. Rizwan Rashid Bazmi, et al. Comparison of anti-inflammatory and analgesic effects of artocarpin-rich Artocarpus heterophyllus extract and artocarpin. Journal of Angiotherapy 6 (2) 601-611.
