76319-15-8
Chemical Structure
Patrinoside aglucone
Synonym(s): Patrinoside aglycone
- CAS No.: 76319-15-8
- Formula:C15H24O6
- Molecular Weight:300.35
InChIKey: PWJFLTCGPYRIGH-SQLGEJSKSA-N
SMILES: CC(C)CC(O[C@H]1[C@@]2([H])[C@@](C[C@@H]([C@@H]2CO)O)([H])C(CO)=CO1)=O
Biological Activity: Patrinoside aglucone (Compound 8) is an iridoid glucoside that can be isolated from the Valeriana tuberosa. Patrinoside aglucone has potent anticancer activity with G2/M phase tumor cell cycle arrest and apoptosis induction. Patrinoside aglucone also significantly inhibits the proliferation of cancer stem cells (such as MDA-MB-231 and U-251MG cells). Patrinoside aglucone has great anti-inflammatory activity by inhibiting NO release (IC50: 43.44 μM) and significantly reduces the level of TNF-α, IL-1β, IL-6, PGE2 and COX-2[1][2].
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Patrinoside aglucone | Patrinoside aglucone (Compound 8) is an iridoid glucoside that can be isolated from the Valeriana tuberosa. Patrinoside aglucone has potent anticancer activity with G2/M phase tumor cell cycle arrest and apoptosis induction. Patrinoside aglucone also significantly inhibits the proliferation of cancer stem cells (such as MDA-MB-231 and U-251MG cells). Patrinoside aglucone has great anti-inflammatory activity by inhibiting NO release (IC50: 43.44 μM) and significantly reduces the level of TNF-α, IL-1β, IL-6, PGE2 and COX-2. | |||||||||||||||||||||
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References
- [1]. Çelik C, et al. Exploring the anti-inflammatory and cytotoxic effects of Valeriana tuberosa L. constituents: Integrating in vitro and in silico studies. Fitoterapia. 2025 Jul;184:106604. [Content Brief]
- [2]. Yoshikawa H, et al. Anti-Proliferative Effects of Iridoids from Valeriana fauriei on Cancer Stem Cells. Int J Mol Sci. 2022 Nov 17;23(22):14206. [Content Brief]
