76472-29-2
76472-29-2
Chemical Structure
ONO-3307
- CAS No.: 76472-29-2
- Formula:C15H18N4O7S2
- Molecular Weight:430.46
IUPAC Name: 4-sulfamoylphenyl 4-guanidinobenzoate methanesulfonate
InChIKey: OSILTPUZIFPGFS-UHFFFAOYSA-N
SMILES: O=C(OC1=CC=C(S(=O)(N)=O)C=C1)C2=CC=C(NC(N)=N)C=C2.CS(=O)(O)=O
Biological Activity: ONO-3307 is a protease inhibitor that competitively inhibits a variety of proteases including trypsin, thrombin, plasma kallikrein, plasmin, pancreatic kallikrein, and chymotrypsin. ONO-3307 alleviates endotoxin-induced experimental disseminated intravascular coagulation (DIC) in rats. ONO-3307 can be used in the study of thrombosis and protease-mediated diseases[1][2].
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ONO-3307 | ONO-3307 is a protease inhibitor that competitively inhibits a variety of proteases including trypsin, thrombin, plasma kallikrein, plasmin, pancreatic kallikrein, and chymotrypsin. ONO-3307 alleviates endotoxin-induced experimental disseminated intravascular coagulation (DIC) in rats. ONO-3307 can be used in the study of thrombosis and protease-mediated diseases. | |||||||||||||||||||||
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References
- [1]. Yoshikawa T, et al. Protective effects of ONO-3307, a new synthetic protease inhibitor against experimental disseminated intravascular coagulation in rats. Thromb Res. 1990 Oct 1;60(1):1-7. [Content Brief]
- [2]. Matsuoka S, et al. Inhibitory effects of ONO-3307 on various proteases and tissue thromboplastin in vitro and on experimental thrombosis in vivo. Jpn J Pharmacol. 1989 Dec;51(4):455-63. [Content Brief]
