76754-24-0
Chemical Structure
Lupalbigenin
- CAS No.: 76754-24-0
- Formula:C25H26O5
- Molecular Weight:406.47
IUPAC Name: 5,7-dihydroxy-3-(4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl)-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
InChIKey: HTAZIHDXIUPDQP-UHFFFAOYSA-N
SMILES: O=C1C2=C(O)C(C/C=C(C)/C)=C(O)C=C2OC=C1C3=CC(C/C=C(C)/C)=C(O)C=C3
Biological Activity: Lupalbigenin is an isoflavonoid compound that can be isolated and extracted from Licorice and Derris scandens. Lupalbigenin exhibits anti-inflammatory, anti-tumor, anti-oxidative stress, anti-metastatic, and anti-dermatophyte effects. Lupalbigenin significantly downregulates key survival factors such as pAKT/AKT, pERK/ERK, and the anti-apoptotic protein BCL-2 in cancer cells, thereby promoting apoptosis. Lupalbigenin is also an insect antifeedant and is toxic to chewing and piercing-sucking insects. Lupalbigenin can be used in cancer and fungal infection research[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Lupalbigenin | 98% | Lupalbigenin is an isoflavonoid compound that can be isolated and extracted from Licorice and Derris scandens. Lupalbigenin exhibits anti-inflammatory, anti-tumor, anti-oxidative stress, anti-metastatic, and anti-dermatophyte effects. Lupalbigenin significantly downregulates key survival factors such as pAKT/AKT, pERK/ERK, and the anti-apoptotic protein BCL-2 in cancer cells, thereby promoting apoptosis. Lupalbigenin is also an insect antifeedant and is toxic to chewing and piercing-sucking insects. Lupalbigenin can be used in cancer and fungal infection research. | ||||||||||||||||||||
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References
- [1]. Chen M, et al. Exploration in the Mechanism of Action of Licorice by Network Pharmacology. Molecules (Basel, Switzerland). 2019 Aug 15;24(16):2959.
- [2]. Fan Z, et al. Heterologous Biosynthesis of Prenylflavonoids in Escherichia coli Based on Fungus Screening of Prenyltransferases. ACS Omega. 2025;10:8891-8900.
- [3]. Sarker SD, et al. All about isowighteone and its hydrate. J Nat Prod Discov. 2026;5(4):3898.
- [4]. Chen Y, et al. Cytotoxicity and Anti-inflammatory Properties of Apigenin-Derived Isolaxifolin. Journal of natural products. 2019 Sep 27;82(9):2451-2459.
- [5]. Mukit TMA, et al. Chemical and biological profiling of Derris scandens (Roxb.) Benth. Bangladesh J Bot. 2024;53(2):227-233.
