769169-27-9
769169-27-9
Chemical Structure
Begacestat
Synonym(s): GSI-953
- CAS No.: 769169-27-9
- Formula:C9H8ClF6NO3S2
- Molecular Weight:391.74
IUPAC Name: (S)-5-chloro-N-(4,4,4-trifluoro-1-hydroxy-3-(trifluoromethyl)butan-2-yl)thiophene-2-sulfonamide
InChIKey: PSXOKXJMVRSARX-SCSAIBSYSA-N
SMILES: FC(F)(F)C([C@H](NS(=O)(C1=CC=C(Cl)S1)=O)CO)C(F)(F)F
Biological Activity: Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC50Aβ40=15 nM) for the treatment of Alzheimer's disease[1].
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Begacestat | 99.05% | Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC50Aβ40=15 nM) for the treatment of Alzheimer's disease. | ||||||||||||||||||||
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Begacestat (Standard) | ≥98% | Begacestat (Standard) is the analytical standard of Begacestat. This product is intended for research and analytical applications. Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC50Aβ40=15 nM) for the treatment of Alzheimer's disease. | ||||||||||||||||||||
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