76996-28-6
Chemical Structure
Garcinone B
- CAS No.: 76996-28-6
- Formula:C23H22O6
- Molecular Weight:394.42
InChIKey: HVXHJNVYRXRHNX-UHFFFAOYSA-N
SMILES: OC(C(C/C=C(C)/C)=C1O)=CC2=C1C(C3=C4C(OC(C)(C)C=C4)=C(O)C=C3O2)=O
Biological Activity: Garcinone B is an NF-κB inhibitor. Garcinone B inhibits LPS-induced NF-κB-dependent transcriptional activation, NF-κB expression, NF-κB-mediated transcription, and IKK, prevents COX-2 transcription, and contributes to immune regulation. Garcinone B inhibits COX enzymes, inhibits prostaglandin E2 release, and contributes to anti-inflammation. Garcinone B blocks ACE2-spike binding, prevents viral entry, inhibits Mpro, and prevents polyprotein cleavage and replication. Garcinone B has antibacterial activity against cariogenic bacteria and bactericidal activity against S. mutans. Garcinone B can be used for research on COVID-19, tuberculosis, and dental caries[1][2][3][4][5].
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Garcinone B | Garcinone B is an NF-κB inhibitor. Garcinone B inhibits LPS-induced NF-κB-dependent transcriptional activation, NF-κB expression, NF-κB-mediated transcription, and IKK, prevents COX-2 transcription, and contributes to immune regulation. Garcinone B inhibits COX enzymes, inhibits prostaglandin E2 release, and contributes to anti-inflammation. Garcinone B blocks ACE2-spike binding, prevents viral entry, inhibits Mpro, and prevents polyprotein cleavage and replication. Garcinone B has antibacterial activity against cariogenic bacteria and bactericidal activity against S. mutans. Garcinone B can be used for research on COVID-19, tuberculosis, and dental caries. | |||||||||||||||||||||
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References
- [1]. Yamakuni T, et al. Garcinone B reduces prostaglandin E2 release and NF-kappaB-mediated transcription in C6 rat glioma cells. Neuroscience letters. 2006 Feb 20;394(3):206-10.
- [2]. Suhandi C, et al. Potency of Xanthone Derivatives from L. for COVID-19 Treatment through Angiotensin-Converting Enzyme 2 and Main Protease Blockade: A Computational Study. Molecules (Basel, Switzerland). 2023 Jul 04;28(13):5187. [Content Brief]
- [3]. Chin YW, et al. Structural Characterization, Biological Effects, and Synthetic Studies on Xanthones from Mangosteen (Garcinia mangostana), a Popular Botanical Dietary Supplement. Mini-reviews in organic chemistry. 2008 Nov 01;5(4):355-364.
- [4]. Liu QY, et al. New insights into the anti-obesity activity of xanthones from Garcinia mangostana. Food & function. 2015 Feb 1;6(2):383-93.
- [5]. Aroonrerk N, et al. Anticariogenic activity of Garcinone B from Garcinia mangostana. SWU Dent J. 2021 Nov 30;14(2):25-34.
