77086-21-6
77086-21-6
Chemical Structure
Dizocilpine
Synonym(s): MK-801
- CAS No.: 77086-21-6
- Formula:C16H15N
- Molecular Weight:221.30
IUPAC Name: (5S,10R)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene
InChIKey: LBOJYSIDWZQNJS-CVEARBPZSA-N
SMILES: C[C@]1(N2)C3=CC=CC=C3C[C@]2([H])C4=CC=CC=C14
Biological Activity: Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a Kd of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dizocilpine | 99.95% | Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a Kd of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux. | ||||||||||||||||||||
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Dizocilpine (Standard) | ≥98% | Dizocilpine (Standard) is the analytical standard of Dizocilpine (HY-15084B). This product is intended for research and analytical applications. Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a Kd of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux. | ||||||||||||||||||||
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References
- [1]. Wong EH, et al. The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci U S A. 1986 Sep;83(18):7104-8. [Content Brief]
- [2]. Wegener N, et al. Evaluation of brain pharmacokinetics of (+)MK-801 in relation to behaviour. Neurosci Lett. 2011 Sep 26;503(1):68-72. [Content Brief]
