77128-69-9
![[Glp5,(Me)Phe8,Sar9] Substance P (5-11) Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-p3801.gif "[Glp5,(Me)Phe8,Sar9] Substance P (5-11) Chemical Structure")
Chemical Structure
[Glp5,(Me)Phe8,Sar9] Substance P (5-11)
Synonym(s): DiMe-C7
- CAS No.: 77128-69-9
- Formula:C43H61N9O9S
- Molecular Weight:880.06
IUPAC Name: 2-(2-amino-4,5-dihydro-1H-imidazol-1-yl-2-13C)acetic-13C2 acid
InChIKey: IEEBRBMEXFNVKU-CVUOCSEZSA-N
SMILES: CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC(CN(C)C([C@H](CC1=CC=CC=C1)N(C)C([C@@H](NC([C@H](CCC(N)=O)NC([C@@H]2CCC(N2)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O
Biological Activity: [Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats[1][2][3].
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[Glp5,(Me)Phe8,Sar9] Substance P (5-11) | 99.61% | [Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats. | ||||||||||||||||||||
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References
- [1]. Elliott PJ, et al. Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area. Brain Res. 1986 Jan 15;363(1):145-7. [Content Brief]
- [2]. Eison AS, et al. Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions. Science. 1982 Jan 8;215(4529):188-90. [Content Brief]
- [3]. Placenza FM, et al. Infusion of the substance P analogue, DiMe-C7, into the ventral tegmental area induces reinstatement of cocaine-seeking behaviour in rats. Psychopharmacology (Berl). 2004 Dec;177(1-2):111-20. [Content Brief]
