77448-64-7
Chemical Structure
Lychnopholide
- CAS No.: 77448-64-7
- Formula:C20H22O6
- Molecular Weight:358.39
IUPAC Name: (3aR,4S,6R,11aR,Z)-6,10-dimethyl-3-methylene-2,7-dioxo-2,3,3a,4,5,6,7,11a-octahydro-6,9-epoxycyclodeca[b]furan-4-yl (E)-2-methylbut-2-enoate
InChIKey: QATUWZPYBIHFFR-AWCNYIIHSA-N
SMILES: C/C=C(C(O[C@@H](C[C@@]1(C)OC(/C(C)=C\2)=CC1=O)[C@]([H])([C@@]2(OC3=O)[H])C3=C)=O)\C
Biological Activity: Lychnopholide is a sesquiterpene lactone derived from the Asteraceae, Lychnopholide exhibits anti-trypanosomal activity against Trypanosoma cruzi. lychnopholide encapsulated in nanocapsules reduces its toxicity to mammalian cells. Lychnopholide ameliorates Chagas disease in mouse models[1].
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Lychnopholide | Lychnopholide is a sesquiterpene lactone derived from the Asteraceae, Lychnopholide exhibits anti-trypanosomal activity against Trypanosoma cruzi. lychnopholide encapsulated in nanocapsules reduces its toxicity to mammalian cells. Lychnopholide ameliorates Chagas disease in mouse models. | |||||||||||||||||||||
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References
- [1]. Milagre MM, et al., Lychnopholide loaded in surface modified polylactide nanocapsules (LYC-PLA-PEG-NC) cure mice infected by Trypanosoma cruzi strain a prototype of resistance to benznidazole and nifurtimox: First insights of its mechanism of action. Exp Parasitol. 2023 Dec;255:108647. [Content Brief]
