77480-55-8
Chemical Structure
(–)-Mycousnine
Synonym(s): Mycousunin
- CAS No.: 77480-55-8
- Formula:C19H20O8
- Molecular Weight:376.36
IUPAC Name: 1,1'-((4aR,9bS)-3,7,9-trihydroxy-4a-methoxy-8,9b-dimethyl-1-oxo-1,4,4a,9b-tetrahydrodibenzo[b,d]furan-2,6-diyl)bis(ethan-1-one)
InChIKey: WWSUFZCWOJULTK-RBUKOAKNSA-N
SMILES: CO[C@@](OC1=C2C(C)=O)(CC(O)=C3C(C)=O)[C@@](C1=C(C(C)=C2O)O)(C3=O)C
Biological Activity: (–)-Mycousnine is a microbial metabolite and derivative of Usnic Acid (HY-N0656) originally isolated from M. nawae that has antibacterial and antifungal activities. It is active against the Gram-positive bacteria B. subtilis, K. rhizophila, and S. aureus (MICs=4, 8, and 4 g/ml, respectively) but not the Gram-negative bacteria E. coli, S. typhimurium, and K. pneumoniae (MICs=>128 g/ml for all).2 (–)-Mycousnine is also active against the fungi T. mentagrophytes, T. rubrum, and C. albicans (MICs=25, 25, and 100 μg/mL, respectively).
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(–)-Mycousnine | (–)-Mycousnine is a microbial metabolite and derivative of Usnic Acid (HY-N0656) originally isolated from M. nawae that has antibacterial and antifungal activities. It is active against the Gram-positive bacteria B. subtilis, K. rhizophila, and S. aureus (MICs=4, 8, and 4 g/ml, respectively) but not the Gram-negative bacteria E. coli, S. typhimurium, and K. pneumoniae (MICs=>128 g/ml for all).2 (–)-Mycousnine is also active against the fungi T. mentagrophytes, T. rubrum, and C. albicans (MICs=25, 25, and 100 μg/mL, respectively). | |||||||||||||||||||||
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