77879-89-1
Chemical Structure
Gilvocarcin M
- CAS No.: 77879-89-1
- Formula:C26H26O9
- Molecular Weight:482.48
IUPAC Name: 4-((2R,3R,4R,5S)-3,4-dihydroxy-5-((R)-1-hydroxyethyl)tetrahydrofuran-2-yl)-1-hydroxy-10,12-dimethoxy-8-methyl-6H-dibenzo[c,h]chromen-6-one
InChIKey: BYFOTBZTKXSZHH-FUCVEXJHSA-N
SMILES: O=C1C2=CC(C)=CC(OC)=C2C3=CC(OC)=C4C(O)=CC=C([C@@H]5[C@@H]([C@H]([C@H]([C@@H](C)O)O5)O)O)C4=C3O1
Biological Activity: Gilvocarcin M is an antibiotic and can be isolated from S. gilvotanareus. Gilvocarcin M is active against S. aureus at a concentration of 32 µg/ml and inhibits growth of KB cells with the IC50 of 0.52 µg/ml. Gilvocarcin M intercalates into bacteriophage PM2 DNA[1][2][3][4].
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Gilvocarcin M | Gilvocarcin M is an antibiotic and can be isolated from S. gilvotanareus. Gilvocarcin M is active against S. aureus at a concentration of 32 µg/ml and inhibits growth of KB cells with the IC50 of 0.52 µg/ml. Gilvocarcin M intercalates into bacteriophage PM2 DNA. | |||||||||||||||||||||
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References
- [1]. Nakano H,et al. Gilvocarcins, new antitumor antibiotics. 1. Taxonomy, fermentation, isolation and biological activities. J Antibiot (Tokyo). 1981;34(3):266-270. [Content Brief]
- [2]. Morimoto M, et al. Gilvocarcins, new antitumor antibiotics. 3. Antitumor activity. J Antibiot (Tokyo). 1981;34(6):701-707. [Content Brief]
- [3]. Tomita F, et al. Gilvocarcins, new antitumor antibiotics. 4. Mode of action. J Antibiot (Tokyo). 1982 Aug;35(8):1038-41. [Content Brief]
