78287-27-1
Chemical Structure
7-Ethylcamptothecin
- CAS No.: 78287-27-1
- Formula:C22H20N2O4
- Molecular Weight:376.41
IUPAC Name: (S)-4,11-diethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione
InChIKey: MYQKIWCVEPUPIL-QFIPXVFZSA-N
SMILES: O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(CC)C5=CC=CC=C5N=C4C3=C2)=O
Biological Activity: 7-Ethylcamptothecin is a derivative of Camptothecin (HY-16560) and a DNA topoisomerase I inhibitor that exhibits significant antitumor activity against tumor cells. 7-Ethylcamptothecin serves as a key precursor for the synthesis of 20 (S)-O-substituted benzoyl-7-ethylcamptothecin compounds. 7-Ethylcamptothecin is widely used in various tumor-related scientific studies[1][2][3].
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7-Ethylcamptothecin | 99.58% | 7-Ethylcamptothecin is a derivative of Camptothecin (HY-16560) and a DNA topoisomerase I inhibitor that exhibits significant antitumor activity against tumor cells. 7-Ethylcamptothecin serves as a key precursor for the synthesis of 20 (S)-O-substituted benzoyl-7-ethylcamptothecin compounds. 7-Ethylcamptothecin is widely used in various tumor-related scientific studies. | ||||||||||||||||||||
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7-Ethylcamptothecin (Standard) | ≥98% | 7-Ethylcamptothecin (Standard) is the analytical standard of 7-Ethylcamptothecin (HY-N2108). This product is intended for research and analytical applications. 7-Ethylcamptothecin is a derivative of Camptothecin (HY-16560) and a key intermediate in the synthesis of SN-38 (HY-13704). 7-Ethylcamptothecin can be used in tumor-related research. | ||||||||||||||||||||
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7-Ethylcamptothecin-d3-1 | 7-Ethylcamptothecin-d3-1 is the deuterium labeled 7-Ethylcamptothecin (HY-N2108). 7-Ethylcamptothecin is a derivative of Camptothecin (HY-16560) and a key intermediate in the synthesis of SN-38 (HY-13704). 7-Ethylcamptothecin can be used in tumor-related research. | |||||||||||||||||||||
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References
- [1]. Liu Y, et al. A novel camptothecin derivative 3j inhibits Nsclc proliferation via induction of cell cycle arrest by topo I-mediated DNA damage[J]. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 2019, 19(3): 365-374.
- [2]. Kaneda N, et al. Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse[J]. Cancer research, 1990, 50(6): 1715-1720.
- [3]. Supko J G, et al. Pharmacokinetics of the 9-amino and 10, 11-methylenedioxy derivatives of camptothecin in mice[J]. Cancer research, 1993, 53(13): 3062-3069.
