785048-28-4
Chemical Structure
SSR126768A free base
- CAS No.: 785048-28-4
- Formula:C33H31Cl2N3O4
- Molecular Weight:604.52
IUPAC Name: (R)-4-chloro-3-(5-chloro-1-(2,4-dimethoxybenzyl)-3-methyl-2-oxoindolin-3-yl)-N-ethyl-N-(pyridin-3-ylmethyl)benzamide
InChIKey: UENRBNCNIZQNTR-XIFFEERXSA-N
SMILES: O=C(N(CC)CC1=CN=CC=C1)C2=CC=C(Cl)C([C@](C3=C(N4CC5=CC=C(OC)C=C5OC)C=CC(Cl)=C3)(C)C4=O)=C2
Biological Activity: SSR126768A free base is an orally active antagonist for oxytocin receptor, with Ki of 0.44 nM. SSR126768A free base is a tocolytic agent, that antagonizes the Oxytocin (HY-17571)-induced intracellular Ca2+ increase and prostaglandin release in human uterine smooth muscle cells, inhibits thus the Oxytocin (HY-17571)-induced uterine contraction and delays parturition in pregnant rats in labor[1].
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SSR126768A free base | SSR126768A free base is an orally active antagonist for oxytocin receptor, with Ki of 0.44 nM. SSR126768A free base is a tocolytic agent, that antagonizes the Oxytocin (HY-17571)-induced intracellular Ca2+ increase and prostaglandin release in human uterine smooth muscle cells, inhibits thus the Oxytocin (HY-17571)-induced uterine contraction and delays parturition in pregnant rats in labor. | |||||||||||||||||||||
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References
- [1]. Serradeil-Le Gal C, et al., SSR126768A (4-chloro-3-[(3R)-(+)-5-chloro-1-(2,4-dimethoxybenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-ethyl-N-(3-pyridylmethyl)-benzamide, hydrochloride): a new selective and orally active oxytocin receptor antagonist for the prevention of preterm labor. J Pharmacol Exp Ther. 2004 Apr;309(1):414-24. [Content Brief]
