787632-66-0
Chemical Structure
TDP-665759
- CAS No.: 787632-66-0
- Formula:C31H34Cl2IN5O2
- Molecular Weight:706.44
IUPAC Name: (S)-4-((R)-1-(2-amino-4-chlorophenyl)ethyl)-3-(4-chlorophenyl)-7-iodo-1-(3-(4-methylpiperazin-1-yl)propyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
InChIKey: NUKCQDDVORQLDB-OLILMLBXSA-N
SMILES: O=C([C@H](C1=CC=C(Cl)C=C1)N2[C@@H](C3=CC=C(Cl)C=C3N)C)N(CCCN4CCN(C)CC4)C5=CC=C(I)C=C5C2=O
Biological Activity: TDP-665759 is an inhibitor for HDm2:p53 complex, and thus activates p53, inhibits STAT3 signaling pathway (EC50 of 5.90 μM) and the cell viability of p53 expressing A549R (IC50 of 7.02 μM). TDP-665759 induces apoptosis in HepG2. TDP-665759 exhibits antitumor efficacy in mouse models[1].
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TDP-665759 | TDP-665759 is an inhibitor for HDm2:p53 complex, and thus activates p53, inhibits STAT3 signaling pathway (EC50 of 5.90 μM) and the cell viability of p53 expressing A549R (IC50 of 7.02 μM). TDP-665759 induces apoptosis in HepG2. TDP-665759 exhibits antitumor efficacy in mouse models. | |||||||||||||||||||||
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