78832-65-2
Chemical Structure
FA-Leu-Gly-Pro-Ala-OH
- CAS No.: 78832-65-2
- Formula:C23H32N4O7
- Molecular Weight:476.52
IUPAC Name: ((E)-3-(furan-2-yl)acryloyl)-L-leucylglycyl-L-prolyl-L-alanine
InChIKey: ZLFQNOJSYZSINX-PVJKAEHXSA-N
SMILES: C[C@@H](C(O)=O)NC([C@H]1N(C(CNC([C@H](CC(C)C)NC(/C=C/C2=CC=CO2)=O)=O)=O)CCC1)=O
Biological Activity: FA-Leu-Gly-Pro-Ala-OH is a furylacryloyl-terminal tetrapeptide that serves as a substrate for bacterial collagenase and spirochete metalloendopeptidase. FA-Leu-Gly-Pro-Ala-OH is specifically hydrolyzed by spirochete collagenase only at the Leu-Gly bond. FA-Leu-Gly-Pro-Ala-OH can be used to determine the equilibrium constant of peptide bond hydrolysis, and also to detect collagenase-mediated cleavage reactions via turbidimetry based on absorbance reduction[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
FA-Leu-Gly-Pro-Ala-OH | 99.46% | FA-Leu-Gly-Pro-Ala-OH is a furylacryloyl-terminal tetrapeptide that serves as a substrate for bacterial collagenase and spirochete metalloendopeptidase. FA-Leu-Gly-Pro-Ala-OH is specifically hydrolyzed by spirochete collagenase only at the Leu-Gly bond. FA-Leu-Gly-Pro-Ala-OH can be used to determine the equilibrium constant of peptide bond hydrolysis, and also to detect collagenase-mediated cleavage reactions via turbidimetry based on absorbance reduction. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Mäkinen K K, et al. Hydrolysis of the Leu-Gly bond of phenylazobenzyl-oxycarbonyl-l-Pro-l-Leu-Gly-l-Pro-D-Arg (a substrate of microbial collagenases) by treponemes isolated from the subgingival plaque of periodontitis patients[J]. Current Microbiology, 1990, 20(1): 69-74.
- [2]. Tassara E, et al. Proteomic Analysis and Biochemical Characterization of the Nematocyst Extract of the Hydrozoan Velella velella. Mar Drugs. 2024 Oct 12;22(10):468. [Content Brief]
