78842-13-4
78842-13-4
Chemical Structure
2′-Deoxy-2′-fluoroguanosine
- CAS No.: 78842-13-4
- Formula:C10H12FN5O4
- Molecular Weight:285.24
IUPAC Name: 2-amino-9-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one
InChIKey: UXUZARPLRQRNNX-DXTOWSMRSA-N
SMILES: OC[C@@H]1[C@@H](O)[C@@H](F)[C@H](N2C(NC(N)=NC3=O)=C3N=C2)O1
Biological Activity: 2′-Deoxy-2′-fluoroguanosine is a nucleoside analog and potent influenza virus inhibitor with an EC90 value of <0.35 μM against influenza A and B viruses. 2′-Deoxy-2′-fluoroguanosine inhibits influenza virus replication in the upper respiratory tract, thereby ameliorating fever and nasal inflammation[1][2][3].
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2′-Deoxy-2′-fluoroguanosine | 99.90% | 2′-Deoxy-2′-fluoroguanosine is a nucleoside analog and potent influenza virus inhibitor with an EC90 value of <0.35 μM against influenza A and B viruses. 2′-Deoxy-2′-fluoroguanosine inhibits influenza virus replication in the upper respiratory tract, thereby ameliorating fever and nasal inflammation. | ||||||||||||||||||||
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References
- [1]. Tisdale M, et, al. Inhibition of influenza virus transcription by 2'-deoxy-2'-fluoroguanosine. Antimicrob Agents Chemother. 1995 Nov;39(11):2454-8. [Content Brief]
- [2]. Jakeman KJ, et, al. Efficacy of 2'-deoxy-2'-fluororibosides against influenza A and B viruses in ferrets. Antimicrob Agents Chemother. 1994 Aug;38(8):1864-7. [Content Brief]
- [3]. Ikehara M, et al. Studies on Nucleosides and Nucleotides. LXXXVII. Purine Cyclonucleosides. XLII. Synthesis of 2'-Deoxy-2'-fluoroguanosine. Chemical and Pharmaceutical Bulletin, 1981, 29(4): 1034-1038.
