78916-42-4
78916-42-4
Chemical Structure
Amorfrutin B
- CAS No.: 78916-42-4
- Formula:C26H32O4
- Molecular Weight:408.53
IUPAC Name: (E)-3-(3,7-dimethylocta-2,6-dien-1-yl)-2-hydroxy-4-methoxy-6-phenethylbenzoic acid
InChIKey: DKNIJLWIVUCTHW-CPNJWEJPSA-N
SMILES: O=C(O)C1=C(CCC2=CC=CC=C2)C=C(OC)C(C/C=C(C)/CC/C=C(C)\C)=C1O
Biological Activity: Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with Ki values of 19 nM and EC50 values of 73 nM, respectively. Amorfrutin B has hypoglycemic and neuroprotective activities[1][2].
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Amorfrutin B | Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with Ki values of 19 nM and EC50 values of 73 nM, respectively. Amorfrutin B has hypoglycemic and neuroprotective activities. | |||||||||||||||||||||
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References
- [1]. Przepiórska K, et al. Amorfrutin B Protects Mouse Brain Neurons from Hypoxia/Ischemia by Inhibiting Apoptosis and Autophagy Processes Through Gene Methylation- and miRNA-Dependent Regulation. Mol Neurobiol. 2023 Feb;60(2):576-595. [Content Brief]
- [2]. Weidner C, et al. Amorfrutin B is an efficient natural peroxisome proliferator-activated receptor gamma (PPARγ) agonist with potent glucose-lowering properties. Diabetologia. 2013 Aug;56(8):1802-12. [Content Brief]
