78981-49-4
78981-49-4
Chemical Structure
BIM-23027
- CAS No.: 78981-49-4
- Formula:C43H54N8O7
- Molecular Weight:794.94
IUPAC Name: 4-(4-chloro-2-methylphenyl)-7-methoxy-2,2-dimethyl-2H-chromen-8-ol
InChIKey: XDLJZSJKUWEHIA-ZKVPYEFOSA-N
SMILES: O=C([C@@H](NC([C@@H](N(C([C@@H](NC([C@](NC([C@@H](NC1=O)CCCCN)=O)([H])[C@H](O)C)=O)CC2=CC=CC=C2)=O)C)C)=O)CC3=CC=CC=C3)N[C@@H]1CC4=CNC5=CC=CC=C45
Biological Activity: BIM-23027 is a selective agonist of sst2 receptor (EC50=0.32 nM), with similar effect to somatostatin (SRIF), a cyclic tetradecapeptide. BIM-23027 stimulates dopamine release, which is mediated by a Glu-dependent mechanism[1][2].
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BIM-23027 | 99.76% | BIM-23027 is a selective agonist of sst2 receptor (EC50=0.32 nM), with similar effect to somatostatin (SRIF), a cyclic tetradecapeptide. BIM-23027 stimulates dopamine release, which is mediated by a Glu-dependent mechanism. | ||||||||||||||||||||
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References
- [1]. Hathway GJ, et al. Evidence that somatostatin sst2 receptors mediate striatal dopamine release. Br J Pharmacol. 1999 Nov;128(6):1346-52. [Content Brief]
- [2]. McKeen ES, et al. Somatostatin receptors mediating inhibition of basal and stimulated electrogenic ion transport in rat isolated distal colonic mucosa. Naunyn Schmiedebergs Arch Pharmacol. 1995 Oct;352(4):402-11. [Content Brief]
