791807-02-8
Chemical Structure
L-783277
- CAS No.: 791807-02-8
- Formula:C19H24O7
- Molecular Weight:364.39
IUPAC Name: (3S,8S,9S,Z)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-hexahydro-1H-benzo[c][1]oxacyclotetradecine-1,7(8H)-dione
InChIKey: QXPNJMHRUZCEAP-UXBSLASESA-N
SMILES: O=C(O[C@@H](C)C/C=C\1)C2=C(O)C=C(OC)C=C2CCC[C@H](O)[C@H](O)C1=O
Biological Activity: L-783277 (Compound 4) is a MEK inhibitor (IC50 = 4 nM). L-783277 has potent inhibitory activity against a variety of kinases, including VEGFR2/3, FLT1/3/4, MEK1/2, KDR, and PDGFRα, but has low selectivity for the kinase community. L-783277 inhibits viability (IC50 = 22 mM) and cell proliferation (IC50 = 21 mM) of H295R cells. L-783277 could be used in research on cancers such as adrenocortical carcinoma[1][2].
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L-783277 | L-783277 (Compound 4) is a MEK inhibitor (IC50 = 4 nM). L-783277 has potent inhibitory activity against a variety of kinases, including VEGFR2/3, FLT1/3/4, MEK1/2, KDR, and PDGFRα, but has low selectivity for the kinase community. L-783277 inhibits viability (IC50 = 22 mM) and cell proliferation (IC50 = 21 mM) of H295R cells. L-783277 could be used in research on cancers such as adrenocortical carcinoma. | |||||||||||||||||||||
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References
- [1]. Kim Y, et al. Natural and Synthetic Lactones Possessing Antitumor Activities. Int J Mol Sci. 2021 Jan 21;22(3):1052. [Content Brief]
- [2]. Lawnicka H, et al. Resorcylic acid lactone L-783,277 inhibits the growth of the human adrenal cancer cell line H295R in vitro. Int J Immunopathol Pharmacol. 2009 Oct-Dec;22(4):889-95. [Content Brief]
