794466-43-6
Chemical Structure
PBP10
- CAS No.: 794466-43-6
- Formula:C84H127N24O15+
- Molecular Weight:1713.06
IUPAC Name: ((3S,6R,9S,12R,15S,18R,21S,27S,30R)-35-amino-3,15-bis(3-amino-3-oxopropyl)-21-(4-aminobutyl)-12-benzyl-30-carboxy-6,27-bis(3-guanidinopropyl)-35-imino-9-isobutyl-18-isopropyl-4,7,10,13,16,19,22,25,28-nonaoxo-2,5,8,11,14,17,20,23,26,29,34-undecaaza-1l2-borapentatriacontyl)rhodium
InChIKey: LZBRUMYNRGYMFB-STYKJLFMSA-N
SMILES: N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC(CNC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H](CCC(N)=O)NC([C@H](CC1=CC=CC=C1)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC(C2=C(C=CC=C2)C3=C(C=CC(N(CC)CC)=C4)C4=[O+]C5=C3C=CC(N(CC)CC)=C5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: PBP10 is a decapeptide. PBP10 selectively binds to lipoteichoic acid (LTA), lipopolysaccharide (LPS) and phosphatidylinositol-4,5-bisphosphate (PIP2). PBP10 penetrates cell membranes and possesses bactericidal, anti-inflammatory, cell motility-inhibiting and actin assembly-regulating activities. PBP10 is applicable to relevant research on bacterial infections, microbe-induced inflammation, skin and soft tissue infections, as well as sepsis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PBP10 | 96.75% | PBP10 is a decapeptide. PBP10 selectively binds to lipoteichoic acid (LTA), lipopolysaccharide (LPS) and phosphatidylinositol-4,5-bisphosphate (PIP2). PBP10 penetrates cell membranes and possesses bactericidal, anti-inflammatory, cell motility-inhibiting and actin assembly-regulating activities. PBP10 is applicable to relevant research on bacterial infections, microbe-induced inflammation, skin and soft tissue infections, as well as sepsis. | ||||||||||||||||||||
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References
- [1]. Bucki R, et al. Interaction of the gelsolin-derived antibacterial PBP 10 peptide with lipid bilayers and cell membranes. Antimicrob Agents Chemother. 2006;50(9):2932-2940. [Content Brief]
- [2]. Cunningham CC, et al. Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J Biol Chem. 2001;276(46):43390-43399. [Content Brief]
- [3]. Piktel E, et al. Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin. J Nanobiotechnology. 2019;17(1):22. Published 2019 Feb 2. [Content Brief]
